359625-79-9
中文名稱
MIN-101
英文名稱
MIN-101
CAS
359625-79-9
分子式
C22H23FN2O2
分子量
366.43
MOL 文件
359625-79-9.mol
更新日期
2025/10/15 20:15:17
359625-79-9 結(jié)構(gòu)式
基本信息
中文別名
2-[[1-[2-(4-氟苯基)-2-氧代乙基]-4-哌啶基]甲基]-2,3-二氫-1H-異吲哚-1-酮 英文別名
MT210MT-210
MT 210
CYR-101
MIN-101
Roluperidone
CYR-101(Roluperidone)
Roluperidone (CYR-101)
MIN-101
MIN 101
MIN101
CYR-101
CYR 101
CYR101
MT-210
MT 210
MT210
1H-Isoindol-1-one, 2-[[1-[2-(4-fluorophenyl)-2-oxoethyl]-4-piperidinyl]methyl]-2,3-dihydro-
所屬類別
醫(yī)藥中間體物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO:33.33(Max Conc. mg/mL);90.96(Max Conc. mM)
形態(tài)固體
顏色White to yellow
InChIInChI=1S/C22H23FN2O2/c23-19-7-5-17(6-8-19)21(26)15-24-11-9-16(10-12-24)13-25-14-18-3-1-2-4-20(18)22(25)27/h1-8,16H,9-15H2
InChIKeyRNRYULFRLCBRQS-UHFFFAOYSA-N
SMILESC1(=O)C2=C(C=CC=C2)CN1CC1CCN(CC(C2=CC=C(F)C=C2)=O)CC1
常見(jiàn)問(wèn)題列表
用途
MIN-101用于有機(jī)合成、醫(yī)藥中間體等。生物活性
Roluperidone (CYR-101) 是一種新型環(huán)酰胺衍生物，對(duì) 5-HT2A 和 sigma-2 受體具有高親和力，Ki 分別為 7.53 nM 和 8.19 nM。靶點(diǎn)
|
5-HT 2A Receptor 7.53 nM (Ki) |
Sigma-2 Receptor 8.19 nM (Ki) |
體外研究
Roluperidone (CYR-101) also shows binding affinity for α 1 -adrenergic receptors but low or no affinity for muscarinic, cholinergic, and histaminergic receptors. Although Roluperidone (CYR-101) has no affinities for pre- or postsynaptic dopaminergic receptors, it is probable that sigma-2 receptors are implicated in the modulation of dopamine and glutamatergic pathways, as well as in calcium neuronal modulation.