36840-10-5
中文名稱
36840-10-5
英文名稱
4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid)
CAS
36840-10-5
分子式
C20H16N2O6
分子量
380.35
MOL 文件
36840-10-5.mol
36840-10-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 T11875(2E,2E)-4,4-([1,1-二聯(lián)苯]-4,4-叉基二(氨叉基))二(4-氧亞基丁-2-烯酸)
英文別名
4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid)4,4-(4,4-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid)(WX610172)
2-Butenoic acid, 4,4'-([1,1'-biphenyl]-4,4'-diyldiimino)bis[4-oxo-
物理化學(xué)性質(zhì)
沸點(diǎn)758.0±60.0 °C(Predicted)
密度1.444±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 83.33 mg/mL (219.09 mM)
酸度系數(shù)(pKa)3.16±0.10(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
36840-10-5價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-113973 | 36840-10-5 LPA2 antagonist 2 | 36840-10-5 | 1 mg | 1203元 |
| 2026/06/05 | HY-113973 | 36840-10-5 LPA2 antagonist 2 | 36840-10-5 | 5 mg | 2900元 |
| 2026/06/05 | HY-113973 | 36840-10-5 LPA2 antagonist 2 | 36840-10-5 | 10 mg | 4600元 |
常見問(wèn)題列表
生物活性
LPA2 antagonist 2 是一種選擇性 LPA2 拮抗劑，IC50 為 28.3 nM，Ki 為 21.1 nM，比 LPA3 (IC50 為 13.85 μM) 選擇性高 480 倍以上。靶點(diǎn)
IC50: 28.3 nM (LPA 2 ); 13.85 μM (LPA 3 )
體外研究
Lysophosphatidic acid (LPA) is a phospholipid mediator that elicits a host of biological effects including cell proliferation, survival, motility and differentiation. LPA has been shown to regulate cancer cell invasion, metastasis, and resistance to both chemotherapeutics and radiation. LPA2 antagonist 2 (H2L 5226501) inhibits LPA 1 with an Imax of 59.0% at 30 μM.