372105-27-6
中文名稱
372105-27-6
英文名稱
naMitecan
CAS
372105-27-6
分子式
C23H22N4O5
分子量
434.445
MOL 文件
372105-27-6.mol
更新日期
2023/03/20 15:41:23
372105-27-6 結(jié)構(gòu)式
基本信息
中文別名
[C(E),4S]-4-乙基-3,4,12,14-四氫-4-羥基-3,14-二氧-1H-吡喃并[3',4':6,7]吲哚并[1-2,B]喹啉-11-甲醛 11-[O-(2-氨基乙基)肟] 英文別名
ST-1968naMitecan
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, 11-[O-(2-aminoethyl)oxime], [C(E),4S]-
物理化學(xué)性質(zhì)
沸點(diǎn)835.2±75.0 °C(Predicted)
密度1.51±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 250 mg/mL (575.45 mM)
酸度系數(shù)(pKa)11.20±0.20(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
372105-27-6價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/12/22 | HY-14821 | 372105-27-6 Namitecan | 372105-27-6 | 1mg | 2450元 |
| 2025/12/22 | HY-14821 | 372105-27-6 Namitecan | 372105-27-6 | 10mM * 1mLin DMSO | 4780元 |
| 2025/12/22 | HY-14821 | 372105-27-6 Namitecan | 372105-27-6 | 5mg | 5000元 |
常見(jiàn)問(wèn)題列表
生物活性
Namitecan 是一種 topoisomerase I 抑制劑，具有抗腫瘤活性。靶點(diǎn)
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Topoisomerase I
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體外研究
Namitecan and cetuximab cooperate in inhibiting EGFR expression. Namitecan induces a dose-dependent decrease in EGFR expression in the different cell lines. ST1968 induces a comparable level of apoptosis in A431 and A431/TPT cells with IC 50 of 0.21 and 0.29 μM.
體內(nèi)研究
Namitecan (10 mg/kg) in combination with cetuximab (1 mg/mouse) induces synergistic antitumor effects in SCC models as a function of EGFR gene copy number. ST1968 (25 mg/kg) causes acceptable body weight loss and no toxic deaths. ST1968 produces a 100% complete response rate in the mice bearing the A431 tumor, and retains a relevant activity in the topotecan-resistant tumor.