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37300-21-3

中文名稱 聚戊糖多硫醇
英文名稱 Pentosan Sulfuric Polyester
CAS 37300-21-3
分子式 C10H18O21S4
37300-21-3 結(jié)構(gòu)式 37300-21-3 結(jié)構(gòu)式

基本信息

中文別名
聚戊糖多硫醇
英文別名
Xylofuranan sulfate
PENTOSAN POLYSULFATE SOD
Pentosan Sulfuric Polyester
[(2R,3R,4S,5R)-2-hydroxy-5-[(2S,3R,4S,5R)-5-hydroxy-3,4-disulfooxyoxan-2-yl]oxy-3-sulfooxyoxan-4-yl] hydrogen sulfate
[(2R,3R,4S,5R)-2-hydroxy-5-[(2S,3R,4S,5R)-5-hydroxy-3,4-disulfooxy-oxan-2-yl]oxy-3-sulfooxy-oxan-4-yl] hydrogen sulfate
sulfuric acid [(2R,3R,4S,5R)-2-hydroxy-5-[(2S,3R,4S,5R)-5-hydroxy-3,4-disulfoxy-tetrahydropyran-2-yl]oxy-3-sulfoxy-tetrahydropyran-4-yl] ester
所屬類別
化學(xué)試劑:硫醇鹽

物理化學(xué)性質(zhì)

形態(tài)Solid
顏色White to off-white

常見(jiàn)問(wèn)題列表

生物活性
Pentosan Polysulfate 是一種口服生物可利用的半合成藥物,具有抗炎和促軟骨生成的特性。Pentosan Polysulfate 也是一種有效和選擇性的抗 HIV 藥物。Pentosan Polysulfate Sodium 用于間質(zhì)性膀胱炎的研究。
靶點(diǎn)

HIV-1

體外研究

Pentosan polysulfate has been shown to inhibit HIV-1 activity with an ED 50 of 0.19 μg/mL in MT-4 cells. It inhibits HIV-1 antigen expression in HUT-78 cells at an ED 50 of 0.02 μg/mL, and complete inhibition of HIV-1 antigen expression is obtained at a concentration of 4.0 μg/mL.
Pentosan Polysulfate suppresses NF-κB, decreases the proinflammatory actions of TNFα, and decreases high glucose and advanced glycation end products (AGEs) stimulated MCP-1 production.

體內(nèi)研究

Pentosan polysulfate has been shown to decreases interstitial inflammation and glomerulosclerosis in 5/6 nephrectomized rats. Pentosan polysulfate treatment preserves renal function, significantly reduces albuminuria, and markedly decreases the severity of renal lesions, including tubulointerstitial inflammation. Pentosan polysulfate also reduces upregulation of TNFα and proinflammatory genes in aging diabetic kidneys.

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