383124-82-1
383124-82-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T23542 英文別名
YE-1202-[3-Cyano-5-(3,4-dichloro-phenyl)-4,5-dimethyl-5H-furan-2-ylidene]-malononitrile
2-[3-Cyano-5-(3,4-dichlorophenyl)-4,5-dimethyl-2(5H)-furanylidene]propanedinitrile
物理化學(xué)性質(zhì)
沸點(diǎn)419.1±45.0 °C(Predicted)
密度1.42±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度Soluble to 100 mM in DMSO
形態(tài)粉末
顏色White to off-white
應(yīng)用領(lǐng)域
用途1
YE-120 is a GPR35 agonist (EC50 = 32 nM in DMR assays). YE-120 also displays partial agonist activity in a β-arrestin translocation assay (EC50 = 10.2 μM). GPR35 is a Class A, rhodopsin-like G protei n-coupled receptor which is predominantly expressed in immune and gastrointestinal tissue, with notable expression in the ileum (rat and human GPR35), the spleen (rat and murine GPR35) and the pancrea s (human GPR35).