384361-79-9

中文名稱化合物 T28193

英文名稱 2-chloro-N-[[4-(dimethylamino)phenyl]methyl]-N-[3-phenyl-3-(4-propan-2-yloxyphenyl)propyl]acetamide

CAS 384361-79-9

分子式 C29H35ClN2O2

分子量 479.05

MOL 文件 384361-79-9.mol

384361-79-9 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 應(yīng)用領(lǐng)域常見問題列表

基本信息

中文別名

化合物 T28193

英文別名

2-chloro-N-[[4-(dimethylamino)phenyl]methyl]-N-[3-phenyl-3-(4-propan-2-yloxyphenyl)propyl]acetamide

物理化學(xué)性質(zhì)

沸點(diǎn)631.8±55.0 °C(Predicted)

密度1.129±0.06 g/cm3(Predicted)

酸度系數(shù)(pKa)4.81±0.12(Predicted)

應(yīng)用領(lǐng)域

用途一

NPD926 is an inducer of cancel cell death. NPD926 sensitized cells to inhibitors of system x(c)?, a cystine-glutamate antiporter considered to be a potential therapeutic target in cancers including cancer stem cells. Induction of excessive levels of reactive oxygen species (ROS) by small-molecule compounds has been considered a potentially effective therapeutic strategy against cancer cells, which are often subjected to chronic oxidative stress.

常見問題列表

概述

NPD926 是一種靶向谷胱甘肽并誘導(dǎo)癌細(xì)胞死亡的小分子。Xc- 系統(tǒng)和谷胱甘肽是癌癥的治療靶點(diǎn)。NPD926 會導(dǎo)致細(xì)胞谷胱甘肽耗竭并隨后產(chǎn)生活性氧 (ROS)，從而使成纖維細(xì)胞對 Xc- 系統(tǒng)抑制劑敏感。NPD926 是一種具有抗癌活性的 ROS 誘導(dǎo)劑。