3862-25-7

中文名稱 7-羥基-4-膽甾烯-3-酮

英文名稱 (7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

CAS 3862-25-7

分子式 C27H44O2

分子量 400.64

MOL 文件 3862-25-7.mol

更新日期 2026/07/13 18:18:38

3862-25-7 結構式

基本信息物理化學性質安全數據圖譜信息 7-羥基-4-膽甾烯-3-酮價格(試劑級) 常見問題列表

基本信息

中文別名

7-羥基-4-膽甾烯-3-酮
7Α-羥基- 4 -膽固醇-3 -酮
7Α-HYDROXY-4-CHOLESTEN-3-ONE
7Α-HYDROXYCHOLESTENONE
7HCO
ALPHA-HC
Α-HC

英文別名

7HCO
alpha-HC
7α-hydroxycholestenone
7a-Hydroxy-cholestene-3-one
7-Hydroxy-4-cholesten-3-one
7a-Hydroxycholest-4-en-3-one
7a-Hydroxy-4-cholesten-3-one
(7a)-7-Hydroxycholest-4-en-3-one
7alpha-hydroxycholest-4-en-3-one
7 alpha-hydroxy-4-cholesten-3-one

物理化學性質

熔點182-184°C

沸點516.7±29.0 °C(Predicted)

密度1.03±0.1 g/cm3(Predicted)

儲存條件-20°C冷凍

溶解度Chloroform (Slightly), Methanol (Slightly)

酸度系數(pKa)14.49±0.70(Predicted)

形態(tài)Solid

顏色White to Off-White

主要應用clinical testing

InChIKeyIOIZWEJGGCZDOL-RQDYSCIWSA-N

SMILESO=C1CC[C@@]2(C)C(C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCCC(C)C)=C1

安全數據

WGK GermanyWGK 3

存儲類別11 - Combustible Solids

圖譜信息

7-羥基-4-膽甾烯-3-酮(3862-25-7)核磁圖(¹HNMR)

7-羥基-4-膽甾烯-3-酮價格(試劑級)

報價日期	產品編號	產品名稱	CAS號	包裝	價格
2026/06/05	HY-113259	7-羥基-4-膽甾烯-3-酮 7α-Hydroxy-4-cholesten-3-one	3862-25-7	1mg	3500元

常見問題列表

生物活性

7α-Hydroxy-4-cholesten-3-one 是一種由膽固醇合成膽汁酸的中間體。7α-Hydroxy-4-cholesten-3-one 是一種孕烷 X 受體 (PXR) 激動劑。7α-Hydroxy-4-cholesten-3-one 是膽汁酸流失，腸易激綜合征和其他與膽汁酸生物合成缺陷有關的疾病的生物標志物。7α-Hydroxy-cholest-4-en-3-one 也是一種 CYP8B1 的生理底物。

靶點

Endogenous Metabolite
Pregnane X receptor (PXR)

體外研究

7α-Hydroxy-4-cholesten-3-one is found relatively upstream in the biosynthetic pathway to bile acids (e.g. chenodeoxycholic acid). The first step is the incorporation of the 7α-hydroxy group onto cholesterol by cytochrome P450 7A1, and the second step is the oxidation and isomerization of the 3-hydroxy group and the Δ5,6-double bond by 3β-hydroxy steroid dehydrogenase to yield 7α-Hydroxy-4-cholesten-3-one. The deletion of the gene that expresses P450 27A1, which is found downstream in the bile acid pathway, results in the accumulation of the precursor, 7α-Hydroxy-4-cholesten-3-one.

體內研究

7α-Hydroxy-4-cholesten-3-one strongly relates to the hepatic enzymatic activity of CYP7A1 at steady-state conditions as well as during the rapid diurnal changes that occur in the rat. That serum 7α-Hydroxy-4-cholesten-3-one has a pronounced diurnal rhythm.