3862-25-7

中文名稱 7-羥基-4-膽甾烯-3-酮

英文名稱 (7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

CAS 3862-25-7

分子式 C27H44O2

分子量 400.64

MOL 文件 3862-25-7.mol

更新日期 2026/06/01 13:40:25

3862-25-7 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 7-羥基-4-膽甾烯-3-酮價(jià)格(試劑級(jí)) 常見問題列表

基本信息

中文別名

7-羥基-4-膽甾烯-3-酮
7Α-羥基- 4 -膽固醇-3 -酮
7Α-HYDROXY-4-CHOLESTEN-3-ONE
7Α-HYDROXYCHOLESTENONE
7HCO
ALPHA-HC
Α-HC

英文別名

7HCO
alpha-HC
7α-hydroxycholestenone
7a-Hydroxy-cholestene-3-one
7-Hydroxy-4-cholesten-3-one
7a-Hydroxycholest-4-en-3-one
7a-Hydroxy-4-cholesten-3-one
(7a)-7-Hydroxycholest-4-en-3-one
7alpha-hydroxycholest-4-en-3-one
7 alpha-hydroxy-4-cholesten-3-one

物理化學(xué)性質(zhì)

熔點(diǎn)182-184°C

沸點(diǎn)516.7±29.0 °C(Predicted)

密度1.03±0.1 g/cm3(Predicted)

儲(chǔ)存條件-20°C冷凍

溶解度Chloroform (Slightly), Methanol (Slightly)

酸度系數(shù)(pKa)14.49±0.70(Predicted)

形態(tài)Solid

顏色White to Off-White

主要應(yīng)用clinical testing

InChIKeyIOIZWEJGGCZDOL-RQDYSCIWSA-N

SMILESO=C1CC[C@@]2(C)C(C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCCC(C)C)=C1

安全數(shù)據(jù)

WGK GermanyWGK 3

存儲(chǔ)類別11 - Combustible Solids

圖譜信息

7-羥基-4-膽甾烯-3-酮(3862-25-7)核磁圖(¹HNMR)

7-羥基-4-膽甾烯-3-酮價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-113259	7-羥基-4-膽甾烯-3-酮 7α-Hydroxy-4-cholesten-3-one	3862-25-7	1mg	3500元

常見問題列表

生物活性

7α-Hydroxy-4-cholesten-3-one 是一種由膽固醇合成膽汁酸的中間體。7α-Hydroxy-4-cholesten-3-one 是一種孕烷 X 受體 (PXR) 激動(dòng)劑。7α-Hydroxy-4-cholesten-3-one 是膽汁酸流失，腸易激綜合征和其他與膽汁酸生物合成缺陷有關(guān)的疾病的生物標(biāo)志物。7α-Hydroxy-cholest-4-en-3-one 也是一種 CYP8B1 的生理底物。

靶點(diǎn)

Endogenous Metabolite
Pregnane X receptor (PXR)

體外研究

7α-Hydroxy-4-cholesten-3-one is found relatively upstream in the biosynthetic pathway to bile acids (e.g. chenodeoxycholic acid). The first step is the incorporation of the 7α-hydroxy group onto cholesterol by cytochrome P450 7A1, and the second step is the oxidation and isomerization of the 3-hydroxy group and the Δ5,6-double bond by 3β-hydroxy steroid dehydrogenase to yield 7α-Hydroxy-4-cholesten-3-one. The deletion of the gene that expresses P450 27A1, which is found downstream in the bile acid pathway, results in the accumulation of the precursor, 7α-Hydroxy-4-cholesten-3-one.

體內(nèi)研究

7α-Hydroxy-4-cholesten-3-one strongly relates to the hepatic enzymatic activity of CYP7A1 at steady-state conditions as well as during the rapid diurnal changes that occur in the rat. That serum 7α-Hydroxy-4-cholesten-3-one has a pronounced diurnal rhythm.