389574-20-3
中文名稱
389574-20-3
英文名稱
Prasugrel (Maleic acid)
CAS
389574-20-3
分子式
C24H24FNO7S
分子量
489.513
MOL 文件
389574-20-3.mol
389574-20-3 結(jié)構(gòu)式
常見(jiàn)問(wèn)題列表
生物活性
Prasugrel (PCR 4099) Maleic acid，一種噻吩吡啶和前藥，抑制血小板功能。Prasugrel Maleic acid 是一種有效的 P2Y12 受體拮抗劑，抑制 ADP 誘導(dǎo)的血小板聚集。靶點(diǎn)
P2Y12 receptor
體外研究
In rat platelets, Prasugrel (PCR 4099) Maleic acid active metabolite inhibits in vitro platelet aggregation induced by adenosine ADP (10μM) with an IC
50
value of 1.8 μM.
Prasugrel (PCR 4099) Maleic acid acts faster and is significantly more potent than Clopidogrel in vivo. Prasugrel hydrochloride is an inactive prodrug that requires metabolic processing in vivo to generate the active antiplatelet metabolite. Prasugrel (PCR 4099) Maleic acid is rapidly absorbed from the gut. After oral administration of standard-loading doses of 60 mg, maximum plasma levels of the active metabolite are achieved within 1 h, effective, maximum inhibition of platelet aggregation at 1-2 h.