39379-15-2
39379-15-2 結(jié)構(gòu)式
基本信息
PYR-LYENKPRRPYIL
NEUROTENSIN (1-13)
NEUROTENSIN, BOVINE
M.W. 1672.92 C78H121N21O20
NEUROTENSIN (HUMAN, BOVINE, CANINE)
NEUROTENSIN (HUMAN, BOVINE, CANINE) 2ACOH 6H2O
PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU
GLP-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU
PGLU-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU
物理化學(xué)性質(zhì)
應(yīng)用領(lǐng)域
純度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
內(nèi)毒素≤50EU/mg
氨基酸組成分析≤±10%
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-P0234 | 神經(jīng)降壓素 Neurotensin | 39379-15-2 | 1mg | 500元 |
| 2026/06/05 | HY-P0234 | 神經(jīng)降壓素 Neurotensin | 39379-15-2 | 5mg | 1500元 |
| 2026/06/05 | HY-P0234 | 神經(jīng)降壓素 Neurotensin | 39379-15-2 | 10mg | 2100元 |
常見(jiàn)問(wèn)題列表
Neurotensin receptors (NTR)
Neurotensin induces the expression of MIP-2, MCP-1, IL-1β and TNFα in murine microglial cells and stimulates IL-8 secretion in a non-transformed colon epithelial cell line stably transfected with the NTR. The high-affinity NTR, a member of the G-protein coupled receptor (GPCR) family, is present in a majority of human pancreatic and colorectal cancers, suggesting that Neurotensin (NT) may act in an endocrine fashion to affect tumor growth. Acting through the NTR1, Neurotensin is known to stimulate various signal transduction pathways, including intracellular calcium ([Ca 2+ ] i ), the mitogen-activated protein kinases (MAPKs), ERK and JNK, and various PKC isoforms. Treatment of HCT116 cells with Neurotensin (100 nM) significantly increases HCT116 cell migration (~3-fold) compared with vehicle treatment; pretreatment with Curcumin (10 μM) blocksthe stimulatory effect of NT on HCT116 cell migration. ctivation of MEK/ERK by NT and downstream induction of AP-1 transcription factors contributes to the proliferative effects of Neurotensin.