3979-00-8

中文名稱 (2-MERCAPTOETHYL)-GUANIDINE SULFATE

英文名稱 (2-MERCAPTOETHYL)-GUANIDINE SULFATE

CAS 3979-00-8

分子式 C3H11N3O4S2

分子量 217.267

MOL 文件 3979-00-8.mol

3979-00-8 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 (2-MERCAPTOETHYL)-GUANIDINE SULFATE價格(試劑級) 常見問題列表

基本信息

中文別名

(2-巰基乙基)-胍硫酸鹽

英文別名

MEG SULFATE
meg hemisulfate salt
XJKZAAUVINNNNC-UHFFFAOYSA-N
(2-MERCAPTOETHYL)-GUANIDINE SULFATE
1-?(2-?Mercaptoethyl)?guanidine Sulfate
mercaptoethylguanidine hemisulfate salt

物理化學(xué)性質(zhì)

熔點177-178 °C

儲存條件2-8°C

溶解度PBS (7.2): 10 mg/ml

形態(tài)A crystalline solid

安全數(shù)據(jù)

WGK Germany3

圖譜信息

(2-MERCAPTOETHYL)-GUANIDINE SULFATE(3979-00-8)核磁圖(¹HNMR)

(2-MERCAPTOETHYL)-GUANIDINE SULFATE價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-138454	(2-MERCAPTOETHYL)-GUANIDINE SULFATE MEG hemisulfate	3979-00-8	1 mg	595元

常見問題列表

生物活性

MEG (Mercaptoethylguanidine) hemisulfate 是一種有效和選擇性的誘導(dǎo)型 NO 合酶 (iNOS) 的抑制劑，在組織勻漿中抑制 iNOS，ecNOS 和 bNOS 的 EC50 值分別為 11.5，110 和 60 μM。MEG hemisulfate 也有效的過氧亞硝酸鹽清除劑，可抑制過氧亞硝酸鹽誘導(dǎo)的氧化過程。MEG hemisulfate 在許多炎癥實驗?zāi)Ｐ椭芯哂斜Ｗo(hù)作用，包括缺血/再灌注損傷，牙周炎，失血性休克，炎性腸病以及內(nèi)毒素和敗血性休克。

靶點

IC50: 11.5 μM (iNOS), 110 μM (ecNOS), 60 μM (bNOS)

體外研究

MEG (0.1-1000 μM; 18 h) reduces nitrite accumulation in the supernatant of cultured J774.2 macrophages activated with LPS (10 μg/mL) and INF (50 μg/mL). MEG inhibits iNOS activity in homogenates of lungs taken from LPS-treated rats.
MEG (1 μM-3 mM; 3 min) dose-dependently inhibits the peroxynitrite-induced oxidation of cytochrome c ²⁺ and hydroxylation of benzoate.
MEG (1-300 μM) inhibits the suppression of mitochondrial respiration and DNA single strand breakage in response to peroxynitrite in J774 cells.
MEG (300 μM; 30 min) inhibits the suppression of vascular contractility in response to peroxynitrite in thoracic aortic rings.

體內(nèi)研究

MEG (10 mg/kg; i.p. for 5 d) attenuates the degree of lipid peroxidation, protein oxidation, and peroxynitrites level and ameliorated the decrease of antioxidant enzymes activities in the esophagus of rats subjected to caustic burn injury.
MEG (30-60 mg/kg; a single i.p.) decreases mean arterial blood pressure (MAP) of normal rats.
MEG (10 mg/kg; a single i.p.) improves the renal dysfunction and tissue injury induced by ischemia/reperfusion (I/R) of rat kidney.

Animal Model:	Sprague-Dawley rats (200-250 g) were injured the esophagus
Dosage:	10 mg/kg
Administration:	I.p. for 5 days
Result:	Reduced the stenosis index (SI) and the histopathologic damage score. Decreased the malondialdehyde and protein carbonyl content and increased the activities of superoxide dismutase and glutathione peroxidase. Regulated the nitrate and nitrite level.