414858-02-9
中文名稱
普樂(lè)沙福雜質(zhì)F
英文名稱
1,8-bis(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzyl)-1,4,8,11-tetraazacyclotetradecane
CAS
414858-02-9
分子式
C46H84N12
分子量
805.24
MOL 文件
414858-02-9.mol
414858-02-9 結(jié)構(gòu)式
基本信息
中文別名
普樂(lè)沙福雜質(zhì)F鹽酸普樂(lè)沙福雜質(zhì)2
英文別名
Plerixafor Impurity FPlerixafor Impurity 21
Plerixafor Impurity 2 HCl
1,8-Bis[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-Cyclotetradecane
1,8-bis(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzyl)-1,4,8,11-tetraazacyclotetradecane
所屬類別
分析化學(xué)：藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品應(yīng)用領(lǐng)域
用途一
1,8-Bis(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzyl)-1,4,8,11-tetraazacyclotetradecane is an impurity of Plerixafor (P580500), a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin''s lymphoma (NHL) and multiple myeloma (MM).