432029-12-4

中文名稱化合物 T27121

英文名稱 β-D-Glucopyranosiduronic acid, 2-[[4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)benzoyl]amino]-3-[(4-methoxybenzoyl)amino]phenyl

CAS 432029-12-4

分子式 C33H38N4O10

分子量 650.69

MOL 文件 432029-12-4.mol

432029-12-4 結(jié)構(gòu)式

基本信息物理化學性質(zhì) 應用領域常見問題列表

基本信息

中文別名

化合物 T27121

英文別名

YM222714
YM-222714
YM 222714
Darexaban glucuronide
β-D-Glucopyranosiduronic acid, 2-[[4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)benzoyl]amino]-3-[(4-methoxybenzoyl)amino]phenyl

物理化學性質(zhì)

沸點778.9±60.0 °C(Predicted)

密度1.436±0.06 g/cm3(Predicted)

酸度系數(shù)(pKa)2.77±0.70(Predicted)

應用領域

用途一

Darexaban glucuronide, also known as YM-222714, is the major component in plasma after oral administration of darexaban to humans and is the pharmacologically active metabolite. Darexaban (YM150) is a direct inhibitor of factor Xa. It is an experimental drug that acts as an anticoagulant and antithrombotic to prevent venous thromboembolism after a major orthopaedic surgery, stroke in patients with atrial fibrillation and possibly ischemic events in acute coronary syndrome. It is used in form of the maleate. The development of darexaban was discontinued in September 2011.

常見問題列表

概述

Darexaban glucuronide (YM-222714) 是 Darexaban (YM150) 的活性代謝物。Darexaban glucuronide (YM-222714) 具有口服活性和抗血栓作用。