438244-41-8
中文名稱
化合物 T28189
英文名稱
Indazolo(4,3-gh)isoquinolin-6(2H)-one, 2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(methylamino)ethyl)amino)-, dihydrochloride
CAS
438244-41-8
分子式
C20H26Cl2N6O2
分子量
453.365
MOL 文件
438244-41-8.mol
438244-41-8 結構式
基本信息
中文別名
化合物 T28189 英文別名
BBR3438BBR-3438
Nortopixantrone HCl
Nortopixantrone hydrochloride
Indazolo(4,3-gh)isoquinolin-6(2H)-one, 2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(methylamino)ethyl)amino)-, dihydrochloride
應用領域
用途一
Nortopixantrone, also known as BBR-3438, is a DNA topoisomerase inhibitor potentially for thetreatment of gastric cancer, ovarian cancer. BR 3438 exhibited a unique profile of preclinical activity with a superior efficacy against prostatic carcinoma models compared to reference compounds (doxorubicin and losoxantrone). The antitumour efficacy of BBR 3438 against prostatic carcinoma could be the result of a combination of favourable events, including enhanced intracellular accumulation and an increased DNA-binding affinity favouring the accumulation of multiple sublethal or lethal damage.