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4430-35-7

中文名稱 6-MITC; 6 MITC; 6MITC
英文名稱 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE
CAS 4430-35-7
分子式 C8H15NOS2
分子量 205.34
MOL 文件 4430-35-7.mol
4430-35-7 結(jié)構(gòu)式 4430-35-7 結(jié)構(gòu)式

基本信息

中文別名
化合物 T15474
英文別名
6-MITC
6-HITC
6-MITC
6 MITC
6MITC
6-METHYLSULFINYLHEXYL ISOTHIOCYANATE
1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE
Hexane, 1-isothiocyanato-6-(methylsulfinyl)-

物理化學(xué)性質(zhì)

沸點385.9±25.0 °C(Predicted)
密度1.12±0.1 g/cm3(Predicted)
儲存條件Refrigerator, under inert atmosphere
溶解度氯仿(微溶)、甲醇(微溶)
形態(tài)Oil
顏色無色至淡黃色
LogP0.959 (est)

常見問題列表

生物活性
Hesperin 是日本芥末中存在的一種生物活性成分,是一種 Nrf2 活化劑。
靶點

Nrf2

體外研究

Hesperin (6-Methylsulfinylhexyl isothiocyanate, 6-MSITC) is an active compound in wasabi ( Wasabia japonica Matsum.). Whether Hesperin induces cytotoxicity of HUVECs is determined. More than 1 μg/mL of Hesperin markedly induces cytotoxicity and morphological alterations. In subsequent experiments we used Hesperin is used at concentrations of 0-1 μg/mL, to study the anti-coagulant and anti-inflammatory properties of Hesperin in HUVECs.

體內(nèi)研究

Hesperin (6-Methylsulfinylhexyl isothiocyanate, 6-MSITC) activates Nrf2 and induces phase II enzyme genes but this induction is absent in Nrf2-null mice, suggesting that Hesperin is a potential activator of the Nrf2/ARE-dependent detoxification pathway. To determine whether Hesperin ameliorates hepatic steatosis and iron accumulation, wild-type and Nrf2-null mice are fed the following diets for 12 weeks: 1) control diet, 2) high-fat diet (HFD), 3) HFD plus Hesperin (10 mg/kg/day ip), 4) HFD for 6 weeks followed by an iron-supplemented HFD for 6 weeks (HFD/Iron), 5) HFD/Iron plus Hesperin. The HFD increased hepatic triglycerides in both genotypes and Hesperin suppress increased hepatic triglycerides in wild-type mice but do not reduce these triglycerides in Nrf2-null mice.

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