446031-79-4
446031-79-4 結(jié)構(gòu)式
基本信息
SR-180711
SSR180711A
SSR-180711
SSR-180711A
SSR-180711C
SSR-180711A HCl
SSR 180711 hydrochloride
SSR180711 hydrochloride,SSR-180711 hydrochloride
(4-bromophenyl) 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | HY-19411 | hydrochloride SSR180711 hydrochloride | 446031-79-4 | 5mg | 750元 |
| 2026/06/05 | HY-19411 | hydrochloride SSR180711 hydrochloride | 446031-79-4 | 10mM * 1mLin DMSO | 825元 |
| 2026/06/05 | HY-19411 | hydrochloride SSR180711 hydrochloride | 446031-79-4 | 10mg | 1250元 |
常見問題列表
IC50: 30 nM (rat α7 n-AChR) and 18 nM (human α7 n-AChR)
Ki: 22 nM (rat α7 n-AChR) and 14 nM (human α7 n-AChR)
SSR180711 hydrochloride is selective for the α7 receptor subtype compared to α4β2, α3β2, α3β4, and α1β1γδ human n-AChR subtypes (IC
50
>5?μM). SSR180711 hydrochloride (10?μM) has no inhibition (lower than 50%) for the ionic channels, neurotransmitter, or peptide receptors.
SSR180711 hydrochloride (0.01-10000 μM) is a potent partial agonist at human α7 n-AChRs expressed in Xenopus oocytes or GH4C1 cells and elicits typical concentration-dependent inward currents with an EC
50
value of 4.4?μM (2.5-7.8?μM).
SSR180711 hydrochloride rapidly penetrates into the brain (ID
50
=8?mg/kg; p.o.). SSR180711 hydrochloride dose-dependently inhibits the specific [
3H
]α-BTX binding in the mouse brain (ID
50
=8.3 and 7.5?mg/kg for p.o. and i.p., respectively).
SSR180711 hydrochloride (1-10?mg/kg for i.p.; 10-30 mg/kg for p.o.) dose-dependently increases extracellular acetylcholine (ACh) levels in the hippocampus and prefrontal cortex of freely moving rats.
SSR180711 hydrochloride (0.1, 0.3, 1?mg/kg; i.v.) dose-dependently increases firing rate.