473268-46-1
中文名稱
473268-46-1
英文名稱
ADDA 5 hydrochloride
CAS
473268-46-1
更新日期
2023/03/20 15:41:23
分子式
C24H36ClNO2
分子量
406.01
MOL 文件
473268-46-1.mol
473268-46-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T14126 英文別名
ADDA-5)ADDA 5 HCl
ADDA 5 (ADDA5
ADDA 5 hydrochloride
ADDA 5 hydrochloride >=98% (HPLC)
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 65 mg/mL (160.10 mM)
形態(tài)Solid
顏色White to off-white
SMILESOC(CN1CCC(C=CC=C2)=C2C1)COCCC34C[C@H]5C[C@H](C[C@H](C5)C4)C3.[H]Cl
473268-46-1價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-U00448 | 473268-46-1 ADDA 5 hydrochloride | 473268-46-1 | 5mg | 910元 |
| 2026/06/05 | HY-U00448 | 473268-46-1 ADDA 5 hydrochloride | 473268-46-1 | 10mM * 1mLin DMSO | 1001元 |
| 2026/06/05 | HY-U00448 | 473268-46-1 ADDA 5 hydrochloride | 473268-46-1 | 10 mg | 1550元 |
常見問題列表
生物活性
ADDA 5 hydrochloride 是一種部分非競(jìng)爭(zhēng)性的細(xì)胞色素 c 氧化酶 (cytochrome c oxidase (CcO)) 抑制劑，可抑制從人膠質(zhì)瘤細(xì)胞和牛心肌細(xì)胞中分離純化的 CcO 的活性，IC50 值分別為 18.93 μM 和 31.82 μM。靶點(diǎn)
IC50: 18.93 μM (CcO, human glioma), 31.82 μM (CcO, bovine heart)
體外研究
ADDA 5 hydrochloride is a partial non-competitive inhibitor of CcO, with IC 50 s of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively. ADDA 5 inhibits CcO activity in UTMZ and Jx22-derived GSCs, with IC 50 s of 21.4 ± 3.9 μM and 15.5 ± 2.8 μM. ADDA 5 (25 μM) shows a growth inhibitory effect on UTMZ cells, with an EC 50 of 8.17 μM.
體內(nèi)研究
ADDA 5 (8 mg/kg, i.p.) significantly suppresses the growth of tumor in mice. ADDA 5 does not causes detectable toxicity at up to 80 mg/kg in mice.