475-25-2
中文名稱
氧化蘇木精
英文名稱
HEMATEIN
CAS
475-25-2
分子式
C16H12O6
分子量
300.26
MOL 文件
475-25-2.mol
更新日期
2023/03/20 17:41:19
475-25-2 結(jié)構(gòu)式
基本信息
中文別名
蘇木因蘇木紅
海爾丹
天然黑1
氧化蘇木素
氧化蘇木精
氧化蘇木紅
英文別名
hematineHEMATEIN
Hamatein
HAEMATEIN
Hematein,94%
abcolhematinelg
HEMATEIN, STAIN
HYDROXYBRASILEIN
TIMTEC-BB SBB006464
CI75290formicroscopy
物理化學(xué)性質(zhì)
熔點180 °C
沸點361.5°C (rough estimate)
密度1.2766 (rough estimate)
折射率1.4600 (estimate)
儲存條件2-8°C
溶解度少許溶于甲醇
色指數(shù)75290
酸度系數(shù)(pKa)8.02±0.40(Predicted)
形態(tài)結(jié)晶粉末
顏色深棕色
水溶解性0.6g/L(20 ºC)
Merck13,4651
BRN93039
LogP0.560 (est)
氧化蘇木精價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/03/03 | 37084 | 氧化蘇木精 Hematein, Thermo Scientific Chemicals | 475-25-2 | 25g | 3705元 |
| 2025/02/05 | 37084 | 氧化蘇木精 Hematein, Thermo Scientific Chemicals | 475-25-2 | 5g | 725元 |
| 2024/04/30 | C37084 | 氧化蘇木精 Hematein | 475-25-2 | 5g | 718元 |
常見問題列表
生物活性
Hematein 是蘇木精的氧化產(chǎn)物，可作為染料。Hematein 是一種變構(gòu)酪蛋白激酶 II 抑制劑，IC50 為 0.74 μM。Hematein 抑制 Akt/PKB Ser129 磷酸化，Wnt/TCF 途徑并增加肺癌細(xì)胞的凋亡。靶點
|
CKII 0.74 μM (IC 50 ) |
Akt
|
Wnt
|
體外研究
Hematein (10-100 μM; 14 days) inhibits cells growth in A427 lung cancer cells.
Hematein (50 and 100 μM; 48 hours) induces apoptosis in A427 lung cancer cells.
Hematein (50 and 100 μM; 48 hours) inhibits CK2-specific Akt phosphorylation.
Cell Viability Assay
| Cell Line: | A427 (HTB-53) cell line |
| Concentration: | 10-100 μM |
| Incubation Time: | 14 days |
| Result: | Inhibited cells growth. |
Apoptosis Analysis
| Cell Line: | A427 (HTB-53) cell line |
| Concentration: | 50 and 100 μM |
| Incubation Time: | 48 hours |
| Result: | Induced apoptosis in A427 lung cancer cells. |
Western Blot Analysis
| Cell Line: | A427 (HTB-53) cell line |
| Concentration: | 50 and 100 μM |
| Incubation Time: | 48 hours |
| Result: | Inhibited CK2-specific Akt phosphorylation. |
體內(nèi)研究
Hematein (intraperitoneal injections; 50 mg/kg; twice a week for 6 weeks) inhibits tumor growth in A427 lung cancer cell xenografts.
| Animal Model: | Female athymic BALB/c nude mice (6-week-old) |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injections; twice a week for 6 weeks |
| Result: | Inhibited tumor growth in A427 lung cancer cell xenografts. |