477726-77-5

英文名稱 2,4-Bis-(2-aMino-pyriMidin-4-yl)-phenol

CAS 477726-77-5

分子式 C14H12N6O

分子量 280.28

MOL 文件 477726-77-5.mol

477726-77-5 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 應(yīng)用領(lǐng)域常見問題列表

基本信息

英文別名

BMI-1026
2,4-Bis-(2-aMino-pyriMidin-4-yl)-phenol

物理化學(xué)性質(zhì)

沸點(diǎn)651.8±65.0 °C(Predicted)

密度1.430±0.06 g/cm3(Predicted)

酸度系數(shù)(pKa)6.49±0.50(Predicted)

應(yīng)用領(lǐng)域

用途一

BMI-1026 is a potent cdk inhibitor with potential anticancer activity. BMI-1026 induced a strong cell cycle alteration with potent inhibitory activities against cyclin-dependent kinases, collectively known as Cdks. BMI-1026 imposes a potent G(2)-M arrest and mild G(1)-S and S arrests. In vitro BMI-1026 induces a mitotic catastrophe and precocious mitotic exit even in the presence of nocodazole. These defects appeared to lead to apoptotic cell death in tumorigenic cell lines. Consistent with the induction of mitotic defects and apoptosis, BMI-1026 imposed a selective sensitivity to proliferating versus differentiating or growth-arrested mouse keratinocytes. These data suggest that BMI-1026 could be developed as a potential anti-Cdk1 chemotherapeutic agent.

常見問題列表

概述

BMI-1026 是一種周期蛋白依賴性激酶 1 (Cdk1) 抑制劑，IC50 為 2.3 nM。BMI-1026 通過阻滯 G2-M 期誘導(dǎo)細(xì)胞凋亡 (apoptosis)。