495-83-0
495-83-0 結(jié)構(gòu)式
基本信息
中文別名
惕各酰托品因 英文別名
TigloidinTiglyssin
tigloidine
Tigloyltropine
Tigloyltropeine
Tiglylpseudotropine
3α-Tigloyloxytropane
Tigloyl pseudotropine
2-Methylcrotonic acid (1R,5S)-tropan-3β-yl ester
2-Butenoic acid, 2-methyl-, (3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, (2E)-
物理化學(xué)性質(zhì)
沸點(diǎn)290.2±33.0 °C(Predicted)
密度1.06±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
酸度系數(shù)(pKa)10.03±0.40(Predicted)
形態(tài)Oil
顏色Light yellow to yellow
常見(jiàn)問(wèn)題列表
生物活性
Tigloidin 是 atropine 的類似物，具有抗膽堿能的活性。體內(nèi)研究
Tigloidine hydrobromide (20-60 mg/kg, i.p.) fails to protect the mice against the lethal effect of physostigmine, but at 100 mg/kg and above, it protects 80% of the animals against the lethal effect. Tigloidine markedly prevents tremor and salivation produced by tremorine at 80-100 mg/kg, but fails to prevent these effects in doses up to 40 mg/kg. Tigloidine (up to 100 mg/kg, i.p) does not significantly affects reserpine and tetrabenazine induced sedation and ptosis in mice. Tigloidine (25-50 mg/kg, i.p.) also fails to cause any behavioral changes in the cats.