496864-14-3
496864-14-3 結(jié)構(gòu)式
基本信息
中文別名
化合物ALOISINE B 英文別名
Aloisine B5H-Pyrrolo[2,3-b]pyrazine, 6-(4-chlorophenyl)-7-(1-methylethyl)-
應(yīng)用領(lǐng)域
用途一
Aloisine B is a potent and selective CDK and GSK-3 inhibitor. Highest affinity targets: Glycogen Synthase Kinase-3, Beta (Rattus norvegicus (rat)) (IC50 750.0 nM). Other measured targets: Cyclin-Dependent Kinase 1 (CDK1) (IC50 850.0 nM); Cyclin-Dependent Kinase 5 (CDK5) (IC50 13000.0 nM). Aloisine inhibits cell proliferation by arresting cells in both G1 and G2.