504-96-1
504-96-1 結構式
基本信息
Neophytadiene
7,11,15-Trimethyl-3-methylene-1-hexadecene
3-Methylene-7,11,15-trimethylhexadec-1-ene
2-(4,8,12-Trimethyltridecyl)buta-1,3-diene
2-(4,8,12-Trimethyltridecyl)-1,3-butadiene
1-Hexadecene, 7,11,15-trimethyl-3-methylene-
1,3-Butadiene, 2-(4,8,12-trimethyltridecyl)-
7,11,15-trimethyl-3-methylidene-hexadec-1-ene
物理化學性質
常見問題列表
Neophytadiene has cytotoxic on RAW 264.7 cells with an IC
50
of 50 μM.
Neophytadiene (50-100 μM; 30 min) successfully inhibits the NO production level and downregulated inducible nitric oxide synthase (iNOS) production in LPS (1 μg/mL)-induced RAW264.7 cells.
Neophytadiene (25-100 μM; 22 hours) significantly inhibits the NO production and inflammatory cytokines TNF-α, IL-6 and IL-10 and IL-10 in LPS (1 μg/mL)-induced RAW264.7 cells.
Neophytadiene (50 mg/kg; p.o.) shows dose-dependent reduction in the alanine aminotransferase (ALT) level.
Neophytadiene (25-50 mg/kg; p.o.) significantly reduces LPS (10 mg/kg)-increased IL6 and 1L10 levels and in heart tissue.
Neophytadiene (25-50 mg/kg; p.o.) significantly reduces LPS (10 mg/kg)-increased PGE2mRNA expression in heart tissue.
Neophytadiene significantly inhibits LPS (10 mg/kg)-induced NO production and inflammatory cytokines TNF-α, IL-6 and IL-10 and IL-10 in vivo.
| Animal Model: | Adult male Sprague Dawley rats (6-8 weeks) |
| Dosage: | 12 mg/kg, 25 mg/kg, 50 mg/kg |
| Administration: | Oral administration, daily, for 7 days |
| Result: | Decreased haemoglobin (HGB) level, ALT level, and heart tissue TNF-α, IL1β, NF-κB, iNOS, PI3k/AktandMAPK in LPS (10 mg/kg)-treat rats. |