511-26-2
中文名稱
1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
英文名稱
1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
CAS
511-26-2
分子式
C22H34O2
分子量
330.5
MOL 文件
511-26-2.mol
更新日期
2023/03/20 15:41:27
511-26-2 結(jié)構(gòu)式
基本信息
中文別名
化合物MAP4343 英文別名
MAP4343Pregn-5-en-20-one, 3-methoxy-, (3β)-
5-Pregnen-3B-ol-20-one-17a,21,21,21-d4 3-Methyl Ether
1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
物理化學(xué)性質(zhì)
熔點123.5°
比旋光度D18 +18° (c = 1.085 in chloroform)
沸點426.6±45.0 °C(Predicted)
密度1.04±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO: 25 mg/mL (75.64 mM)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
MAP4343 是 Pregnenolone 的 3-甲基醚衍生物。MAP4343 在體外與微管相關(guān)蛋白 2 (MAP2) 結(jié)合，刺激微管蛋白的聚合，增強神經(jīng)突的延伸并保護神經(jīng)元免受神經(jīng)毒性劑的侵害。體外研究
MAP4343 (40 μM; 15 or 30 min) stimulates microtubule polymerization in vitro.
MAP4343 (30 μM; 2-8 d) stimulates nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells.
MAP4343 (20 μM; 1 h) protects against microtubule depolymerization induced by Nocodazole in PC12 cells
體內(nèi)研究
MAP4343 (12 mg/kg; daily s.c. for 28 d) improves the recovery of locomotor function after spinal cord injury (SCI) in rats.
MAP4343 (4 mg/kg; daily s.c. for 6 d) increases MAP2 levels in spinal cord after SCI in rats.
MAP4343 (4 mg/kg; daily s.c. for 6 d) increases the size of lumbar spinal motoneurons' dendrite arbours after SCI in rats.
| Animal Model: | Adult Sprague-Dawley male rats with spinal cord injury |
| Dosage: | 12 mg/kg |
| Administration: | Daily s.c. for 28 days |
| Result: |
Increased the number of animals able to walk with weight-supported plantar steps.
Showed forelimb-hindlimb coordination at the end of the study. |