512177-83-2

中文名稱 (5R)-4-乙?；?1-(4-氯-2-氟苯基)-5-環(huán)己基-1,5-二氫-3-羥基-2H-吡咯-2-酮

英文名稱 2H-Pyrrol-2-one, 4-acetyl-1-(4-chloro-2-fluorophenyl)-5-cyclohexyl-1,5-dihydro-3-hydroxy-, (5R)-

CAS 512177-83-2

分子式 C18H19ClFNO3

分子量 351.8

MOL 文件 512177-83-2.mol

更新日期 2024/06/25 17:15:56

512177-83-2 結構式

基本信息物理化學性質(zhì) 圖譜信息 (5R)-4-乙?；?1-(4-氯-2-氟苯基)-5-環(huán)己基-1,5-二氫-3-羥基-2H-吡咯-2-酮價格(試劑級) 常見問題列表

基本信息

中文別名

(R)-4-乙?；?1-(4-氯-2-氟苯基)-5-環(huán)己基-3-羥基-1H-吡咯-2(5H)-酮
(5R)-4-乙酰基-1-(4-氯-2-氟苯基)-5-環(huán)己基-1,5-二氫-3-羥基-2H-吡咯-2-酮

英文別名

187305
(R)-4-Acetyl-1-(4-chloro-2-fluorophenyl)-5-cyclohexyl-3-hydroxy-1H-pyrrol-2(5H)-one
(R)-4-acetyl-1-(4-chloro-2-fluorophenyl)-5-cyclohexyl-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one
(5R)-4-Acetyl-1-(4-chloro-2-fluorophenyl)-5-cyclohexyl-1,5-dihydro-3-hydroxy-2H-pyrrol-2-one
2H-Pyrrol-2-one, 4-acetyl-1-(4-chloro-2-fluorophenyl)-5-cyclohexyl-1,5-dihydro-3-hydroxy-, (5R)-

物理化學性質(zhì)

沸點482.6±45.0 °C(Predicted)

密度1.383±0.06 g/cm3(Predicted)

儲存條件-20°C儲存

溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 1 mg/ml

酸度系數(shù)(pKa)4.50±1.00(Predicted)

形態(tài)結晶固體

顏色White to off-white

圖譜信息

(5R)-4-乙?；?1-(4-氯-2-氟苯基)-5-環(huán)己基-1,5-二氫-3-羥基-2H-吡咯-2-酮(512177-83-2)核磁圖(¹HNMR)

(5R)-4-乙?；?1-(4-氯-2-氟苯基)-5-環(huán)己基-1,5-二氫-3-羥基-2H-吡咯-2-酮價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-50081	(5R)-4-乙?；?1-(4-氯-2-氟苯基)-5-環(huán)己基-1,5-二氫-3-羥基-2H-吡咯-2-酮 CCR2-RA-[R]	512177-83-2	5 mg	880元
2026/06/05	HY-50081	(5R)-4-乙酰基-1-(4-氯-2-氟苯基)-5-環(huán)己基-1,5-二氫-3-羥基-2H-吡咯-2-酮 CCR2-RA-[R]	512177-83-2	10 mM * 1 mL in DMSO	968元
2026/06/05	HY-50081	(5R)-4-乙?；?1-(4-氯-2-氟苯基)-5-環(huán)己基-1,5-二氫-3-羥基-2H-吡咯-2-酮 CCR2-RA-[R]	512177-83-2	10 mg	1400元

常見問題列表

生物活性

CCR2-RA-[R] 是C-C趨化因子受體2型 (C-C chemokine receptor type 2 (CCR2)) 的變構拮抗劑，IC50 值為103 nM。

靶點

CCR2

103 nM (IC ₅₀ , in U2OS-CCR2 cells)

體外研究

The chemokine receptor CCR2 is a G protein-coupled receptor that is involved in many diseases characterized by chronic inflammation, and therefore a large variety of CCR2 small molecule antagonists has been developed. CCR2-RA-[R] displaces [ ¹²⁵ I]CCL2 from CCR2 with an pIC ₅₀ value of 6.1. The pK _D of CCR2-RA-[R] for CCR2 and CCR5 is 8.8±0.1 and 7.0±0.1, respectively. CCR2-RA-[R] inhibits CCR2 non-competitively by blocking activation-associated conformational changes and formation of the G protein-binding interface. The binding pocket of CCR2-RA-[R] is highly enclosed and possesses a balanced combination of hydrophobic and polar features, all of which favors pocket “druggability”.