536711-20-3
536711-20-3 結(jié)構(gòu)式
物理化學性質(zhì)
沸點790.530±60.00 °C(Press: 760.00 Torr)(predicted)
密度1.545±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
酸度系數(shù)(pKa)10.923±0.20(predicted)
應(yīng)用領(lǐng)域
用途一
S39625 is an E-ring camptothecin keto analogue. S39625 is stable, potent, and selective topoisomerase I inhibitor without being substrates of drug efflux transporters. Nanomolar concentrations of S39625 induces intense and persistent histone gamma-H2AX. The chemical stability of the keto analogues and the ability of S39625 to produce high levels of persistent Top1-DNA cleavage complex and its potent antiproliferative activity against human cancer cell lines make S39625 a promising new anticancer drug candidate. Histone gamma-H2AX could be used as a biomarker for the upcoming clinical trials of S39625.