55084-08-7
中文名稱
黃芩黃酮II
英文名稱
NEOBAICALEIN
CAS
55084-08-7
分子式
C19H18O8
分子量
374.34
MOL 文件
55084-08-7.mol
更新日期
2026/06/08 20:02:40
55084-08-7 結(jié)構(gòu)式
基本信息
中文別名
黃芩新素黃芩黃酮II
黃芩新素II
美黃芩黃酮II
黃芩新素II(美黃芩黃酮II)
英文別名
NEOBAICALEINSkullcapflavone Ⅱ
Skullcapflavon II
SKULLCAPFLAVONE II
scullcapflavone II
Skullcapflavone II >=90% (LC/MS-UV)
2',5-Dihydroxy-6,6',7,8-tetramethoxyflavone
4H-1-Benzopyran-4-one, 5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxy-
所屬類別
有機原料：酮類化合物物理化學(xué)性質(zhì)
外觀性狀白色結(jié)晶，可溶于甲醇、乙醇、DMSO等有機溶劑，來源于五味子。
沸點636.9±55.0 °C(Predicted)
密度1.375±0.06 g/cm3(Predicted)
儲存條件-20°C
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
酸度系數(shù)(pKa)6.81±0.40(Predicted)
形態(tài)粉末
顏色黃色
主要應(yīng)用metabolomics
vitamins, nutraceuticals, and natural products
vitamins, nutraceuticals, and natural products
InChIInChI=1S/C19H18O8/c1-23-11-7-5-6-9(20)13(11)12-8-10(21)14-15(22)17(24-2)19(26-4)18(25-3)16(14)27-12/h5-8,20,22H,1-4H3
InChIKeyGMQFOKBGMKVUQZ-UHFFFAOYSA-N
SMILESC1(C2=C(OC)C=CC=C2O)OC2=C(OC)C(OC)=C(OC)C(O)=C2C(=O)C=1
常見問題列表
黃芩
黃芩為唇形科多年生草本。其有效成分為黃芩素、黃芩甙、漢黃芩素、黃芩新素等5種黃酮成分。此外，還含有β-谷甾醇、苯甲酸、黃芩酶等。有抑菌、抗病毒、鎮(zhèn)靜、利尿、保肝、保膽、解毒、消炎及使血糖上升等作用。主要用于治療爛鰓病、癤瘡病、打印病、出血性敗血癥、腸炎病等。生物活性
Skullcapflavone II 是從黃芩中提取的黃酮類化合物，具有抗炎、抗菌作用。Skullcapflavone II 調(diào)節(jié)破骨細胞的分化、存活和功能。Skullcapflavone II 對 M. aurum 和M. bovis BCG 具有較強的抗菌活性。體外研究
Skullcapflavone II inhibits osteoclastogenesis with decreased activation of MAPKs, Src, and cAMP response element-binding protein (CREB), which have been known to be redox sensitive. Skullcapflavone II decreases reactive oxygen species by scavenging them or activating nuclear factor-erythroid 2-related factor 2 (Nrf2), and its effects were partially reversed by hydrogen peroxide cotreatment or Nrf2 deficiency.
體內(nèi)研究
Skullcapflavone II, a potential bradykinin antagonist, reduces the major pathophysiological features of allergic asthma, at least in part by acting on TGF-β1/Smad signaling pathways.