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571186-50-0

中文名稱 571186-50-0
英文名稱 11BETA,17,21-TRIHYDROXY-PREGN-4-ENE-3,20-DIONE METHYL ESTER 3-[(NITROOXY) METHYL]-BENZOIC ACID
CAS 571186-50-0
分子式 C29H35NO9
分子量 541.59
MOL 文件 571186-50-0.mol
571186-50-0 結(jié)構(gòu)式 571186-50-0 結(jié)構(gòu)式

基本信息

中文別名
化合物 T16278
英文別名
NCX 1022
NO-HYDROCORTISONE
Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-[[4-[(nitrooxy)methyl]benzoyl]oxy]-, (11β)-
11BETA,17,21-TRIHYDROXY-PREGN-4-ENE-3,20-DIONE METHYL ESTER 3-[(NITROOXY) METHYL]-BENZOIC ACID

物理化學(xué)性質(zhì)

沸點(diǎn)734.2±60.0 °C(Predicted)
密度1.37±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)12.31±0.70(Predicted)

常見問題列表

生物活性
NCX1022 是一種釋放 NO 的 Hydrocortisone 衍生物,Hydrocortisone 是用于皮膚炎癥的相關(guān)研究。
體內(nèi)研究

Topical pre- and post-treatment with NCX1022 (3 nmol) in C57BL6 mice not only reduces ear oedema formation in a dose-dependent manner, but also is significantly more effective than the parent compound during the initial stages of inflammation (from 1 to 5 h). NCX1022, but not Hydrocortisone, significantly inhibits granulocyte recruitment (tissue myeloperoxidase activity). Histological samples of mouse ears treated with NCX1022 show significant reduction in both the number of infiltrated cells and disruption of the tissue architecture compared to Hydrocortisone-treated tissues. Post-treatment with Hydrocortisone does not modify the increased granulocyte infiltration induced by benzalkonium application, but NCX1022 reduces by 63% the myeloperoxidase (MPO) activity, producing a maximum effect at the dose of 3 nmol per ear. NCX1022 is significantly more potent than Hydrocortisone in reducing contact dermatitis-induced leukocyte adhesion, particularly at the early time points (e.g., 30-60 min after dermatitis induction).

"571186-50-0" 相關(guān)產(chǎn)品信息
50-03-3 56-47-3
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