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57649-10-2

中文名稱 3-amino-3-deoxy-D-glucose hydrochloride
英文名稱 3-amino-3-deoxy-D-glucose hydrochloride
CAS 57649-10-2
分子式 C6H13NO5.ClH
MOL 文件 57649-10-2.mol
57649-10-2 結(jié)構(gòu)式 57649-10-2 結(jié)構(gòu)式

基本信息

中文別名
化合物 T11743
英文別名
Kanosamine hydrochloride >=97.0% (TLC)
(2R,3S,4S,5R)-3-amino-2,4,5,6-tetrahydroxyhexanal:hydrochloride

物理化學(xué)性質(zhì)

儲存條件-20°C儲存
溶解度≤5mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide
形態(tài)結(jié)晶固體
顏色White to off-white
穩(wěn)定性非常吸濕

常見問題列表

生物活性
Kanosamine hydrochloride是一種抗生素,可抑制植物病原卵菌,某些真菌 (fungi) 和細(xì)菌 (bacterial) 的生長。Kanosamine抑制 Phytophthora medicaginis M2913 和 Aphanomyces euteiches WI-98的MIC 分別為25 和 60 μg/mL。
靶點(diǎn)

MIC: 25 μg/mL ( Phytophthora medicaginis M2913), 60 μg/mL ( Aphanomyces euteiches WI-98)

體外研究

Kanosamine is highly inhibitory to growth of plant-pathogenic oomycetes. Among the strains tested, Phytophthora medicaginis M2913 is the most sensitive to kanosamine, whereas Pythium aphanidermatum Pa138 and Pythium torulosum A25a are less sensitive, and Aphanomyces euteiches WI-98 shows an intermediate level of sensitivity. The oomycetes are more sensitive to kanosamine at pH 7.0 than at pH 5.6. Kanosamine inhibits few bacterial species. Kanosamine is moderately inhibitory to certain fungi. All of the fungi and oomycetes inhibited by kanosamine are pathogens of plants. Maximum accumulation of kanosamine in B. cereus UW85 culture supernatants coincided with sporulation. Kanosamine accumulation is enhanced by the addition of ferric iron and suppressed by addition of phosphate to rich medium. Kanosamine accumulation is also enhanced more than 300% by the addition of alfalfa seedling exudate to minimal medium. The antibiotic kanosamine inhibits growth of Saccharomyces cerevisiae and a range of human pathogenic fungi, including Candida albicans . The action of kanosamine on C. albicans cells results in profound morphological changes, inhibition of septum formation and cell agglutination.

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