57935-66-7
中文名稱
尼麥角林雜質(zhì)Ⅵ(EP雜質(zhì)E)
英文名稱
Ergoline-8-methanol, 10-hydroxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8β)-
CAS
57935-66-7
分子式
C23H24BrN3O3
分子量
470.37
MOL 文件
57935-66-7.mol
更新日期
2026/07/16 17:37:54
57935-66-7 結(jié)構(gòu)式
基本信息
中文別名
尼麥角林雜質(zhì)07尼麥角林雜質(zhì)Ⅵ(EP雜質(zhì)E)
英文別名
NicergolineImpurity210α-Hydroxy Nicergoline
Ergoline-8-methanol Indolo[4,3-fg]quinoline Derivative
Ergoline-8-methanol, 10-hydroxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8β)-
所屬類別
分析化學(xué)：藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品物理化學(xué)性質(zhì)
沸點(diǎn)621.7±55.0 °C(Predicted)
密度1.54±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)13.80±0.40(Predicted)
應(yīng)用領(lǐng)域
用途一
10α-Hydroxy Nicergoline is an impurity of Nicergoline (N394550) which is a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia. Nicergoline has shown to protect cultured neurons against β-amyloid toxicity. Nicergoline protects against neuronal cell death induced by activated microglia and astrocytes through the inhibition of inflammatory mediators and the upregulation of neurotrophic factors by glial cells. Nicergoline is a drug used for age-dependent cognitive impairment and it protects cultured neurons against β-amyloid toxicity.