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57966-42-4

中文名稱 ARG--TYR--LEU--PRO-THR
英文名稱 PROCTOLIN
CAS 57966-42-4
分子式 C30H48N8O8
分子量 648.75
MOL 文件 57966-42-4.mol
57966-42-4 結(jié)構(gòu)式 57966-42-4 結(jié)構(gòu)式

基本信息

中文別名
直腸肽
2-[[1-[2-[[2-[[2-AMINO-5-(DIAMINOMETHYLIDENEAMINO)PENTANOYL]AMINO]-3-(4-HYDROXYPHENYL)PROPANOYL]AMINO]-4-METHYLPENTANOYL]PYRROLIDINE-2-CARBONYL]AMINO]-3-HYDROXYBUTANOIC ACID
英文別名
Proctolin【Periplaneta americana】
L-Arg-L-Tyr-L-Leu-L-Pro-L-Thr-OH
L-Threonine, L-arginyl-L-tyrosyl-L-leucyl-L-prolyl-
2-[[1-[2-[[2-[[2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoicacid

物理化學(xué)性質(zhì)

密度1.43±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
酸度系數(shù)(pKa)3.28±0.10(Predicted)
形態(tài)粉末
顏色White to off-white
水溶解性Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
序列Arg-Tyr-Leu-Pro-Thr

常見問題列表

生物活性
Proctolin 是一種內(nèi)源性五肽,用作興奮性神經(jīng)調(diào)節(jié)劑。
體外研究

Proctolin can increase the frequency of action potentials, increase the amplitude of muscle contraction, and initiate activity in quiescent systems. In the arthropods, Proctolin acts as a neuromodulator and possibly as a neurohormone. It does not appear to function as a conventional neurotransmitter. Proctolin is a pentapeptide with the mature peptide of RYLPT, and it is the first insect neuropeptide to be sequenced and chemically characterized. The first identification of a Proctolin precursor gene is CG7105 in D. melanogaster . Although a previous study showed that Proctolin is absent in B. mori , this pentapeptide is recently identified in a proteomic analysis of B. mori wings. However, the Bombyx Proctolin gene does not produce a mature peptide because cleavage sites are not present at the N-terminal and C-terminal of the RYLPT sequence, and a similar gene is observed in C. suppressalis . Therefore, a true Proctolin has been considered to be not observed in B. mori and C. suppressalis .

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