58001-19-7
中文名稱
尼麥角林雜質(zhì)Ⅶ(EP雜質(zhì)F)
英文名稱
Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8α)-
CAS
58001-19-7
分子式
C24H26BrN3O3
分子量
484.39
MOL 文件
58001-19-7.mol
更新日期
2026/07/16 17:38:02
58001-19-7 結(jié)構(gòu)式
基本信息
中文別名
尼麥角林雜質(zhì)Ⅶ(EP雜質(zhì)F) 英文別名
IsonicergolineErgoline-8-methanol, 10-methoxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8α)-
((6aR,9S,10aS)-10a-methoxy-4,7-dimethyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methyl 5-bromonicotinate
所屬類別
分析化學(xué)：對(duì)照品物理化學(xué)性質(zhì)
沸點(diǎn)594.4±50.0 °C(Predicted)
密度1.47±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)6.33±0.40(Predicted)
InChIKeyYSEXMKHXIOCEJA-HWXJYTLHNA-N
SMILESO([C@]12C[C@H](COC(C3=CN=CC(Br)=C3)=O)CN(C)[C@]1([H])CC1=CN(C)C3=CC=CC2=C13)C |&1:1,3,18,r|
應(yīng)用領(lǐng)域
用途一
8-epi Nicergoline is an impurity of Nicergoline (N394550) which is a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia. Nicergoline has shown to protect cultured neurons against β-amyloid toxicity. Nicergoline protects against neuronal cell death induced by activated microglia and astrocytes through the inhibition of inflammatory mediators and the upregulation of neurotrophic factors by glial cells. Nicergoline is a drug used for age-dependent cognitive impairment and it protects cultured neurons against β-amyloid toxicity.