585-23-9
中文名稱(chēng)
化合物 ALBIZZIIN
英文名稱(chēng)
3-[(aminocarbonyl)amino]alanine
CAS
585-23-9
分子式
C4H9N3O3
分子量
147.133
MOL 文件
585-23-9.mol
585-23-9 結(jié)構(gòu)式
基本信息
中文別名
化合物 ALBIZZIIN 英文別名
2-Amino-3-ureidopropanoic acid3-[(aminocarbonyl)amino]alanine
(3S)-3-amino-3-ureido-propionic acid
(3S)-3-amino-3-(carbamoylamino)propanoic acid
3-[(Aminocarbonyl)amino]-2-aminopropionic acid
(3S)-3-(aminocarbonylamino)-3-azanyl-propanoic acid
物理化學(xué)性質(zhì)
沸點(diǎn)359.1±42.0 °C(Predicted)
密度1.430±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)2.15±0.10(Predicted)
應(yīng)用領(lǐng)域
用途一
Albizziin is amino acid analog which acts as a competitive inhibitor of asparagine synthetase with respect to glutamine. Albizziin has been used to isolate mutants of Chinese hamster ovary cells with alterations in levels of the target enzyme. Several classes of mutations can be distinguished on the basis of cross-resistance to beta-aspartyl hydroxamate, another amino acid analog. Studies on asparagine synthetase indicate that resistance to albizziin may be due to altered regulation of asparagine synthetase, structural mutations of the enzyme, and gene amplification.