586-06-1
586-06-1 結(jié)構(gòu)式
基本信息
奧西那林
間羥異丙基腎上腺素
5-(1-hydroxy-2-propan-2-ylamino-ethyl)benzene-1,3-diol
orciprenaline
1-(3,5-dihydroxyphenyl)-2-isopropylaminoethanol
1,3-Benzenediol, 5-1-hydroxy-2-(1-methylethyl)aminoethyl-
1,3-Benzenediol, 5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]- (9CI)
3,5-Dihydroxy-a-[(isopropylamino)methyl]benzyl alcohol
Benzyl alcohol, 3,5-dihydroxy-a-[(isopropylamino)methyl]- (6CI, 8CI)
3,5-dihydroxy-alpha-((isopropylamino)methyl)benzyl alcohol
3,5-dihydroxy-alpha-((isopropylamino)methyl)-benzyl alcohol
5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-3-benzenediol
5-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,3-benzenediol
Metaproterenol (base and/or unspecified salts)
3,5-Dihydroxy-α-[(isopropylamino)methyl]benzyl alcohol
5-[2-(Isopropylamino)-1-hydroxyethyl]-1,3-benzenediol
物理化學(xué)性質(zhì)
常見問題列表
IC50: 68 nM (β2-adrenergic receptor)
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages.
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages.
Western Blot Analysis
| Cell Line: | THP-1 cells and bone marrow macrophages |
| Concentration: | 10 μM |
| Incubation Time: | 74 hours |
| Result: | Enhanced β-arrestin2 and its interaction with IκBα. |
RT-PCR
| Cell Line: | THP-1 cells and bone marrow macrophages |
| Concentration: | 10 μM |
| Incubation Time: | 74 hours |
| Result: | Led to downregulation of NF-κB. |
Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.