5947-49-9

中文名稱羅漢松酸

英文名稱 PODOCARPIC ACID

CAS 5947-49-9

分子式 C17H22O3

分子量 274.35

MOL 文件 5947-49-9.mol

5947-49-9 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息羅漢松酸價格(試劑級) 常見問題列表

基本信息

中文別名

羅漢松酸, >99%

英文別名

Nsc 231784
PODOCARPIC ACID
Einecs 227-706-3
Podocarpic acid 98%
Podocarpic acid, >99%
12-HYDROXYPODOCARPA-8,11,13-TRIEN-16-OIC ACID
Podocarpa-8,11,13-trien-16-oic acid, 12-hydroxy- (van) (8ci)
1 4A-DIMETHYL-6-HYDROXY-1 2 3,4A 9 10 10A-OCTAHYDRO-1-PHENANTHRENECARBOXYLIC ACID
1,2,3,4,4a,9,10,10aβ-Octahydro-6-hydroxy-1,4aα-dimethyl-1α-phenanthrenecarboxylic acid
(1S)-1,2,3,4,4aβ,9,10,10aα-Octahydro-6-hydroxy-1,4a-dimethyl-1-phenanthrenecarboxylic acid

所屬類別

有機原料：羧酸類化合物及衍生物

物理化學(xué)性質(zhì)

熔點193-196 °C (lit.)

比旋光度20546 +165° (c = 4 in abs ethanol)

沸點449.6±45.0 °C(Predicted)

密度1.182±0.06 g/cm3(Predicted)

儲存條件-20°C儲存

溶解度DMSO: ≥ 100 mg/mL (364.50 mM)

酸度系數(shù)(pKa)4.66±0.40(Predicted)

形態(tài)Solid

顏色White to off-white

旋光度 (Optical Rotation)[α]20/D +133°, c = 4 in ethanol

Merck13,7625

InChI1S/C17H22O3/c1-16-8-3-9-17(2,15(19)20)14(16)7-5-11-4-6-12(18)10-13(11)16/h4,6,10,14,18H,3,5,7-9H2,1-2H3,(H,19,20)/t14-,16-,17+/m1/s1

InChIKeyVJILEYKNALCDDV-OIISXLGYSA-N

SMILES[H][C@@]12CCc3ccc(O)cc3[C@@]1(C)CCC[C@]2(C)C(O)=O

安全數(shù)據(jù)

WGK Germany3

存儲類別11 - Combustible Solids

圖譜信息

羅漢松酸(5947-49-9)核磁圖(¹HNMR)
羅漢松酸(5947-49-9)Raman光譜
羅漢松酸(5947-49-9)紅外圖譜(IR)

羅漢松酸價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-N2318	羅漢松酸 Podocarpic acid	5947-49-9	5 mg	220元
2026/06/05	HY-N2318	羅漢松酸 Podocarpic acid	5947-49-9	10 mM * 1 mL in DMSO	242元
2026/06/05	HY-N2318	羅漢松酸 Podocarpic acid	5947-49-9	10mg	353元

常見問題列表

生物活性

Podocarpic acid 是一種天然產(chǎn)物，為 TRPA1 的激活劑，具有多種功效。

體外研究

Podocarpic acid anhydride acts as a 1 nM agonist of LXRalpha and beta receptors. It shows over 8-10-fold better activator of LXR receptors compared to one of the natural ligands, 22-(R)-hydroxy cholesterol, in HEK-293 cells.

體內(nèi)研究

Podocarpic acid activates SKN-1 in C. elegans, similar to known Nrf2 activators such as α-lipoic acid (LA). Podocarpic acid- or LA-induced SKN-1 activation also requires TRPodocarpic acid-1: trPodocarpic acid-1 knockdown in glod-4;gst-4p::gfp animals reduces expression of gst-4 to wild-type levels. A and LA supplementation results in a robust Ca ²⁺ flux, which is significantly reduces when the Ca ²⁺ -impermeable TRPodocarpic acid-1E1018A channel is present, suggesting that TRPodocarpic acid-1 activation is key for these drugs' function. Finally, Podocarpic acid and LA alleviate the Podocarpic acidthogenic phenotypes of glod-4 animals by reverting the high endogenous MGO and GO to almost wild-type-like levels.