60117-17-1
中文名稱
甲硫氨酸腦啡肽酰胺
英文名稱
Met-enkephalinamide
CAS
60117-17-1
分子式
C27H36N6O6S
分子量
572.68
MOL 文件
60117-17-1.mol
更新日期
2023/04/14 14:06:23
60117-17-1 結(jié)構(gòu)式
基本信息
中文別名
甲硫氨酸腦啡肽酰胺 英文別名
5-Methionine-enkephalin amideL-Methioninamide, L-tyrosylglycylglycyl-L-phenylalanyl-
所屬類別
生物化工：多肽物理化學(xué)性質(zhì)
熔點(diǎn)142-145 °C
沸點(diǎn)1066.7±65.0 °C(Predicted)
密度1.303±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)9.97±0.15(Predicted)
序列Tyr-Gly-Gly-Phe-Met-NH2
常見問(wèn)題列表
生物活性
[Met5]-Enkephalin, amide 是一種 δ 和 ζ 阿片受體 (opioid receptor) 激動(dòng)劑。靶點(diǎn)
δ and ζ opioid receptor
體外研究
[Met5]-Enkephalin at 0.1 nM, 10 nM, and 1 μM significantly reduces the total number of glial cells in culture. [Met5]-Enkephalin, amide acts via δ-opioid receptor to inhibit pelvic nerve-evoked contractions of cat distal colon. [Met5]-enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC 50 value of 2.2 nM. [Met5]enkephalin at a concentration (3 nM) which produces a large inhibition of neurogenic contractions, has no effect on contractions to exogenous acetylcholine.