63119-27-7
63119-27-7 結(jié)構(gòu)式
基本信息
中文別名
阿尼扎芬 英文別名
LY-122512anitrazafen
5,6-Bis(p-methoxyphenyl)-3-methyl-1,2,4-triazine
5,6-Bis(4-methoxyphenyl)-3-methyl-1,2,4-triazine
1,2,4-Triazine, 5,6-bis(4-methoxyphenyl)-3-methyl-
物理化學(xué)性質(zhì)
沸點(diǎn)482.8±55.0 °C(Predicted)
密度1.164±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)1.85±0.63(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
Anitrazafen 是一種局部有效的抗炎劑。體內(nèi)研究
Anitrazafen is a topically effective antiinflammatory agent. The disposition of 14 C in normal and in bile-duct cannulated rats after oral administration of a single dose of 25 mg/kg of [3- 14 C]Anitrazafen shows the drug to be well absorbed from the gastro-intestinal tract and biliary excretion to be the major route of elimination of drug and/or metabolites. Plasma concentrations of total 14 C after subcutaneous administration of [3- 14 C]Anitrazafen in corn oil solution are about one half those found after oral administration.