633-35-2
中文名稱
雄甾-1,4,6-三烯-3,17-二酮
英文名稱
ANDROSTA-1,4,6-TRIENE-3,17-DIONE
CAS
633-35-2
分子式
C19H22O2
分子量
282.38
MOL 文件
633-35-2.mol
633-35-2 結(jié)構(gòu)式
基本信息
中文別名
雄甾-1,4,6-三烯-3,17-二酮ATD (1,4,6三烯-雄甾-3,17-二酮)
英文別名
Δ1,4,6-androgen1,4,6-Andorstatriene-3,17-dione
androsta-1,4,6-triene-3,17-dione
1,4,6-Androstatriene-3,17-dione(ATD)
Androsta-1,4,6-triene-3,17-dione (1.0mg/mL in MeOH)
物理化學(xué)性質(zhì)
熔點(diǎn)164-1650C
沸點(diǎn)452.8±45.0 °C(Predicted)
密度1.16±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C冷凍
溶解度methanol: 50 mg/mL, soluble
形態(tài)powder
常見問題列表
生物活性
Androsta-1,4,6-triene-3,17-dione 是親脂性、特異性的芳香酶 (aromatase) 抑制劑，Ki 值為 0.18 μM。Androsta-1,4,6-triene-3,17-dione 可抑制雌激素生物合成，具有避孕作用。Androsta-1,4,6-triene-3,17-dione 能誘導(dǎo)空間記憶障礙。靶點(diǎn)
Ki: 0.18 μM (aromatase)
體內(nèi)研究
Androsta-1,4,6-triene-3,17-dione (25-100 mg/kg; s.c.) prevents the normal rise in ovarian estradiol concentrations.
Androsta-1,4,6-triene-3,17-dione may act in vivo to inhibit fertility by inhibition of estrogen biosynthesis .
| Animal Model: | Rats (220-250 g) |
| Dosage: | 25 mg/kg, 100 mg/kg |
| Administration: | Subcutaneous injection |
| Result: | Prevented the normal rise in ovarian estradiol concentrations with a single injection 3 hours before the time of the estrogen surge on proestrus. |