63335-25-1
中文名稱
馬拉巴酮C
英文名稱
Malabaricone C
CAS
63335-25-1
分子式
C21H26O5
分子量
358.43
MOL 文件
63335-25-1.mol
更新日期
2026/07/27 08:36:42
63335-25-1 結(jié)構(gòu)式
基本信息
中文別名
馬拉巴酮C 英文別名
Malabaricone C1-(2,6-Dihydroxyphenyl)-9-(3,4-dihydroxyphenyl)-1-nonanone
1-(2,6-dihydroxyphenyl)-9-(3,4-dihydroxyphenyl)nonan-1-one
1-Nonanone, 1-(2,6-dihydroxyphenyl)-9-(3,4-dihydroxyphenyl)-
所屬類別
有機(jī)原料：酮類化合物物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml
形態(tài)結(jié)晶固體
顏色White to off-white
InChIInChI=1S/C21H26O5/c22-16-13-12-15(14-20(16)26)8-5-3-1-2-4-6-9-17(23)21-18(24)10-7-11-19(21)25/h7,10-14,22,24-26H,1-6,8-9H2
InChIKeyHCOZRFYGIFMIEX-UHFFFAOYSA-N
SMILESC(C1=C(O)C=CC=C1O)(=O)CCCCCCCCC1=CC=C(O)C(O)=C1
應(yīng)用領(lǐng)域
用途一
Malabaricone C is a diarylnonanoid that has been found in Myristica and has diverse biological activities. It scavenges 59.9% of 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals when used at a concentration of 7 μg/ml. Malabaricone C is active against S. aureus, B. subtilis, and C. albicans in vitro (MICs = 2-32 μg/ml). It is cytotoxic to A549, HL-60, and MCF-7 cells (IC50s = 12.3, 46.1, and 10.8 μM, respectively). Malabaricone C inhibits sphingomyelin synthase 1 (SMS1) and SMS2 activity in cell lysates (IC50s = 3 and 1.5 μM, respectively). It decreases body weight gain, hepatic steatosis, and hepatic and plasma triglyceride levels in a mouse model of high-fat diet-induced obesity when administered at a dose of 0.1% in the diet.