634911-80-1

中文名稱 3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯

英文名稱 3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester

CAS 634911-80-1

分子式 C11H18FNO5

分子量 263.26

MOL 文件 634911-80-1.mol

更新日期 2024/11/15 18:20:32

634911-80-1 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯價(jià)格(試劑級) 常見問題列表

基本信息

中文別名

3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯

英文別名

Caspase Inhibitor Boc-D-FMK
Caspase3-Inhibitor Boc-D-FMK
1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-
3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester
Pentanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]aMino]-5-fluoro-4-oxo-, Methyl ester
BOC-D-FMK (Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester)

所屬類別

有機(jī)原料：羧酸酯及其衍生物

物理化學(xué)性質(zhì)

沸點(diǎn)383.5±37.0 °C(Predicted)

密度1.150

儲存條件-20°C

溶解度DMSO: 5mg/mL

酸度系數(shù)(pKa)10.12±0.46(Predicted)

形態(tài)<31.2°C Solid,>31.2°C Liquid

顏色Light yellow to yellow

InChIInChI=1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)

InChIKeyMXOOUCRHWJYCAL-UHFFFAOYSA-N

SMILESC(OC)(=O)CC(NC(OC(C)(C)C)=O)C(=O)CF

安全數(shù)據(jù)

WGK GermanyWGK 1

存儲類別11 - Combustible Solids

圖譜信息

3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯(634911-80-1)核磁圖(¹HNMR)

3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯價(jià)格(試劑級)

報(bào)價(jià)日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價(jià)格
2026/06/05	HY-13229R	3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯 BOC-D-FMK (Standard)	634911-80-1	1 mg	1440元
2026/06/05	HY-13229R	3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯 BOC-D-FMK (Standard)	634911-80-1	5 mg	3000元
2026/06/05	HY-13229	3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯 BOC-D-FMK	634911-80-1	1 mg	500元

常見問題列表

生物活性

Boc-D-FMK 是可滲透細(xì)胞，不可逆的，泛半胱天冬酶 (caspase) 抑制劑。Boc-D-FMK 抑制 TNF-α 誘導(dǎo)的細(xì)胞凋亡的 IC50 值為 39 μM。

靶點(diǎn)

Caspase

體外研究

Apoptosis is a pathway of cell death orchestrated by a family of proteases called caspases. Boc-D-fmk inhibits TNFα-stimulated reactive oxygen species (ROS) generation. Boc-D-FMK inhibits apoptosis stimulated by TNF-α with an IC ₅₀ of 39 μM. BocD-fmk at 50 μM prevents genistein-induced apoptosis of p815 cells. Confocal microscopy shows that the release of mitochondrial apoptotic factors is inhibited by BocD-fmk.

體內(nèi)研究

Boc-D-FMK-fmk effectively attenuates the hepatocyte apoptosis in bile duct-ligated rats and may improve the survival rates after endotoxin challenge. A single injection of Boc-D-FMK results in longterm protection of MNs against root avulsion-induced death for more than 8 weeks and the Boc-D-FMK-treated MNs are able to regenerate their axons into an implanted PN graft and reinnervate the target muscle.