64302-87-0
64302-87-0 結(jié)構(gòu)式
基本信息
R162
R-162
R 162
2-Allyl-1-hydroxy-9,10-anthraquinone
9,10-Anthracenedione, 1-hydroxy-2-(2-propen-1-yl)-
物理化學(xué)性質(zhì)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-103096 | R162 R162 | 64302-87-0 | 1 mg | 400元 |
| 2026/06/05 | HY-103096 | R162 R162 | 64302-87-0 | 5 mg | 880元 |
| 2026/06/05 | HY-103096 | R162 R162 | 64302-87-0 | 10 mM * 1 mL in DMSO | 968元 |
常見(jiàn)問(wèn)題列表
Inhibition of GDH1 activity by R162 treatment results in decreased intracellular fumarate levels, attenuated GPx activity, increased ROS levels, and reduced cell proliferation in H1299 and MDA-MB231 cells, which can be significantly rescued by methyl-α-KG treatment as well as by antioxidant NAC. R162 inhibits cell proliferation and tumor growth potential of human cancer cells.
R162 (30 mg/kg/day, i.p.) does not result in a significant histopathological change between the vehicle-treated and R162-treated groups, nor alters complete blood counts, or hematopoietic properties in xenograft tumor mouse models. R162 (20 mg/kg/day) results in significantly decreased tumor growth and masses in mice compared with control mice and effectively inhibits GDH1 activity in resected tumors from xenograft nude mice.