6637-10-1
中文名稱
化合物VPC-13163
英文名稱
2,3-dihydro-2,3'-Bi-1H-indole
CAS
6637-10-1
分子式
C16H14N2
分子量
234.3
MOL 文件
6637-10-1.mol
6637-10-1 結(jié)構(gòu)式
基本信息
中文別名
化合物VPC-13163 英文別名
NSC52361VPC13163
VPC 13163
VPC-13163
NSC 52361
3-dihydro-2
3'-Bi-1H-indole
2,3-dihydro-2,3'-Bi-1H-indole
2,3'-Bi-1H-indole, 2,3-dihydro-
應(yīng)用領(lǐng)域
用途一
VPC-13163 has strong anti-proliferative activity against LNCaP and Enzalutamide-resistant prostate cancer cell lines (MR49F) whereas it did not affect the growth of AR independent PC3 cell line. It also inhibits Prostate Specific Antigen (PSA) in both LNCaP and MR49F and reduces expression of AR target genes, PSA and TMPRSS2. These findings suggest that VPC-13566 exhibits AR BF3 specific mechanism of action.