674-38-4
674-38-4 結(jié)構(gòu)式
基本信息
中文別名
氨甲酰甲膽堿苯乙二酚-D6
氨甲酰甲膽堿-D6
英文別名
BETHANECOLCarbamyl-β-methylcholine
Carbamoyl-β-methylcholine
1-Propanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-
Ammonium, (2-hydroxypropyl)trimethyl-, carbamate (ester) (8CI)
常見(jiàn)問(wèn)題列表
生物活性
Bethanechol 是一種擬副交感神經(jīng)劑。Bethanechol 是毒蕈堿型受體 (mAChR) 的激動(dòng)劑，通過(guò)直接刺激副交感神經(jīng)系統(tǒng)的 mAChR (M1、M2、M3、M4、M5) 發(fā)揮其作用。靶點(diǎn)
mAChR
體外研究
Bethanechol (0.3-300 μM) significantly reduces ileal pacemaker potentials, significantly.
體內(nèi)研究
Bethanechol (2-12 mg/kg; i.p.) induces drinking and increased urine output of rats in a dose-dependent fashion.
| Animal Model: | Female rats of the Blue Spruce Farms (Sprague-Dawley) (280-330 g) |
| Dosage: | 2 mg/kg, 4 mg/kg, 8 mg/kg, 12 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Increased water intake during the first hr in a dose-dependent fashion up to the highest dose administered (12 mg/kg). |