67452-97-5
67452-97-5 結(jié)構(gòu)式
基本信息
中文別名
阿氯米松 英文別名
VadermAlclometasone
AlcloMethasone
ALCLOMETHASONE DIPROPIONATE
7α-Chloro-16α-methylprednisolone
7α-Chloro-16α-methyl Prednisolone
7α-Chloro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
(7α,11β,16α)-7-Chloro-11,17,21-trihydroxy-16-Methylpregna-1,4-diene-3,20-dione
Pregna-1,4-diene-3,20-dione, 7-chloro-11,17,21-trihydroxy-16-methyl-, (7α,11β,16α)-
物理化學(xué)性質(zhì)
熔點(diǎn)176-179°
比旋光度D26 +47.5° (c = 0.3 in DMF)
沸點(diǎn)607.1±55.0 °C(Predicted)
密度1.34±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)12.30±0.70(Predicted)
常見問題列表
生物活性
Alclometasone (7a-Chloro-16a-methyl prednisolone) 是一種糖皮質(zhì)激素 (glucocorticoid)，可抑制白細(xì)胞促炎性介質(zhì)的釋放。Alclometasone 可用于緩解皮質(zhì)類固醇反應(yīng)性皮膚病，包括特應(yīng)性皮炎，濕疹，牛皮癬和過敏性皮炎。靶點(diǎn)
IC50: glucocorticoid receptor
體內(nèi)研究
The prodrug of alclometasone is alclometasone dipropionate.Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) inhibits the activity of androgen-dependent cytochrome P450 and O-depropylation activity as a dose-dependent manner in male Slc-Wistar strain rats. However, it has no effects on hepatic drug metabolism in female rats or DS strain mice.