6837-93-0
中文名稱
4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
英文名稱
4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
CAS
6837-93-0
分子式
C17H15NO9S3
分子量
473.5
MOL 文件
6837-93-0.mol
6837-93-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 T163514-氨基-5-(對(duì)甲苯磺酰氧基)萘-2,7-二磺酸
英文別名
4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid1-Amino-8-(4-methylphenylsulfonyloxy)naphthalene-3,6-disulfonic acid
4-amino-5-(4-methylphenyl)sulfonyloxynaphthalene-2,7-disulfonic acid
8-Amino-1-(4-methylphenylsulfonyloxy)-3,6-naphthalenedisulfonic acid
4-Amino-5-[[(4-methylphenyl)sulfonyl]oxy]-2,7-naphthalenedisulfonic acid
2,7-Naphthalenedisulfonic acid, 4-amino-5-[[(4-methylphenyl)sulfonyl]oxy]-
物理化學(xué)性質(zhì)
密度1.5197 (rough estimate)
折射率1.7000 (estimate)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 31.25 mg/mL (66.00 mM)
酸度系數(shù)(pKa)-1.16±0.40(Predicted)
形態(tài)Solid
顏色Off-white to gray
常見問題列表
生物活性
NSC16168 是特異性 ERCC1-XPF 的抑制劑，其 IC50 值為0.42 μM。NSC16168 可抑制 DNA 修復(fù)，增強(qiáng) CDDP 對(duì)癌癥的療效。靶點(diǎn)
IC50: 0.42 μM (ERCC1-XPF).
體外研究
NSC16168 (0-50 μM) potentiates cisplatin efficacy in cancer cells.
Cell Viability Assay.
| Cell Line: | H460 cells. |
| Concentration: | 0-50 μM. |
| Incubation Time: | 2 h. |
| Result: | Potentiated cisplatin efficacy in cancer cells. |
體內(nèi)研究
NSC16168 (20 mg/kg, ip, twice daily) exhibits significant anti-tumor activity and potentiates cisplatin antitumor activity in H460 lung cancer xenografts.
| Animal Model: |
2.5×10
6
H460 cells were injected s.c. in the right flank of each mouse.
|
| Dosage: | 20 mg/kg. |
| Administration: | IP, twice daily for 10 days. |
| Result: |
The tumor growth was minimally affected by compound and the mice displayed no signs of distress or toxic side effects.
The combination treatment with 16168 and cisplatin inhibited H460 tumor growth, which was maintained for the duration of the compound injections. |