688763-65-7
688763-65-7 結(jié)構(gòu)式
基本信息
中文別名
化合物 T27255 英文別名
SB-656933SB-656933AAF
SB-656933-AAF
SB-656933 AAF
Elubrixin HCl
Elubrixin hydrochloride
1-(2-chloro-3-fluorophenyl)-3-(4-chloro-2-hydroxy-3-piperazin-1-ylsulfonylphenyl)urea:hydrochloride
1-(2-Chloro-3-fluorophenyl)-3-[4-chloro-2-hydroxy-3-(piperazine-1-sulfonyl)phenyl]urea (Hydrochloride)
應(yīng)用領(lǐng)域
用途一
Elubrixin, also known as SB-656933 or SB-656933-AAF, is a interleukin 8 inhibitor and CXCR2 selective antagonist, which is potentially useful for Inflammatory bowel disease therapies. Elubrixin inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans. demonstrates dose-dependent effects on neutrophil activation and recruitment within a well-tolerated dose range. SB-656933 may be an effective agent in neutrophil-predominant diseases.