69014-14-8
69014-14-8 結(jié)構(gòu)式
基本信息
中文別名
硫替丁 英文別名
TIOTIDINEICI-125211
1-cyano-3-[2-[(2-guanidinothiazol-4-yl)methylthio]ethyl]-2-methyl-guanidine
1-Methyl-2-cyano-3-[2-[2-(diaminomethyleneamino)thiazole-4-ylmethylthio]ethyl]guanidine
1-Methyl-2-cyano-3-[2-[[2-(diaminomethyleneamino)thiazole-4-yl]methylthio]ethyl]guanidine
N-[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazoyl]methyl]thio]ethyl]-N'-cyano-N''-methylguanidine
N'-Cyano-N-[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]-N''-methylguanidine
N-[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]-N'-cyano-N''-methylguanidine
1-cyano-3-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-2-methylguanidine
1-[2-[[2-[bis(azanyl)methylideneamino]-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-3-cyano-2-methyl-guanidine
物理化學(xué)性質(zhì)
沸點(diǎn)490.1±55.0 °C(Predicted)
密度1.50±0.1 g/cm3(Predicted)
儲(chǔ)存條件Store at RT
溶解度Soluble to 10 mM in ethanol and to 100 mM in DMSO
酸度系數(shù)(pKa)pKa 6.80 (Uncertain)
形態(tài)粉末
顏色White to yellow
硫替丁價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/12/22 | HY-101232 | 硫替丁 Tiotidine | 69014-14-8 | 1mg | 545元 |
| 2025/12/22 | HY-101232 | 硫替丁 Tiotidine | 69014-14-8 | 5mg | 1200元 |
| 2025/12/22 | HY-101232 | 硫替丁 Tiotidine | 69014-14-8 | 10mM * 1mLin DMSO | 1320元 |
常見(jiàn)問(wèn)題列表
生物活性
Tiotidine (ICI 125211) 是一種有效選擇性 H2 受體 (histamine H2-receptor) 拮抗劑 (pA2=7.3-7.8)。Tiotidine (ICI 125211) 對(duì) H1 和 H3 受體均具有低親和力。靶點(diǎn)
|
H 2 Receptor 7.3-7.8 (pA2) |
H 3 Receptor 4.8 (pA2) |
體外研究
Tiotidine competitively antagonizes the positive chronotropic action of histamine with an apparent dissociation constant of 30 μM (23-38 μM). Tiotidine abolishes H2-mediated increases in contractile force leaving H2-mediated negative inotropic responses unopposed. The actions of histamine at the A-V node, manifested by lengthening of the P-R interval and A-V block, are attenuated by 2.5 x 10(-7) M Tiotidine.
Tiotidine actually behaves as an inverse agonist in U-937 cells, diminishing basal cAMP levels.