69579-13-1
69579-13-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T15455 英文別名
RGH-5526GYKI 11679
3-[2-[6-(4-Morpholinyl)-3-pyridazinyl]hydrazono]butanoic acid 1,1-dimethylethyl ester
Butanoic acid, 3-[2-[6-(4-morpholinyl)-3-pyridazinyl]hydrazinylidene]-, 1,1-dimethylethyl ester
物理化學(xué)性質(zhì)
沸點472.04°C (rough estimate)
密度1.0974 (rough estimate)
折射率1.7500 (estimate)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
常見問題列表
生物活性
RGH-5526 (GYKI-11679) 是一種新型的抗高血壓藥。體內(nèi)研究
RGH-5526 (GYKI-11679) is a new antihypertensive agent. Results show a sharp (61%) reduction in the hypothalamic Noradrenaline (NA) level 2 h after the administration of 10 mg/kg of RGH-5526, and this effect lasts for 4 to 6 h. It is demonstrated that RGH-5526 exerts a greater NA lowering effect in the hypothalamus than in the periphery. RGH-5526 does not influence the hypothalamic monoamine oxidase (MAO)-activity following prolonged treatment.