69698-54-0
69698-54-0 結(jié)構(gòu)式
基本信息
VIP(血管活性腸肽)(6-28)三氟乙酸鹽
血管活性腸肽VIP(6-28)(HUMAN, RAT, PORCINE, BOVINE)
Aviptadil (6-28)
M.W. 2816.31 C126H207N37O34S
VIP (6-28) (huMan, Mouse, rat)
VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT)
VIP (6-28) (HUMAN, RAT, PORCINE, BOVINE)
VIP(6-28)(HUMAN, RAT, PORCINE, BOVINE)?, >98%
vasoactive intestinal peptide*fragment 6-28 porci
6-28-Vasoactive intestinal octacosapeptide (swine)
VASOACTIVE INTESTINAL PEPTIDE FRAGMENT 6-28 PORCINE
物理化學(xué)性質(zhì)
應(yīng)用領(lǐng)域
純度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
內(nèi)毒素≤50EU/mg
氨基酸組成分析≤±10%
常見問題列表
VIP
VIP(6-28) is an effective VIP antagonist in the superior cervical ganglion (SCG) , and results obtained using this analog indicate that endogenous VIP can participate in a positive feedback loop in injured sympathetic neurons in which it enhances its own expression. VIP(6-28), when added to short-term cultures of adult SCG at a concentration of 10, 30, or 100 μM, reduces the increase in cAMP levels produced by stimulation with 10 μM VIP by 52, 64, or 81%, respectively. At any of these concentrations tested, VIP(6-28) by itself does not alter cAMP levels. In contrast to its ability to reduce the VIP-stimulated elevation in cAMP levels by 64%, the addition of 30 μM VIP(6-28) to culture medium does not significantly alter cAMP levels measured after stimulation of adult ganglia with either isoproterenol or forskolin (10 μM each). Similar results on the ability of VIP(6-28) to block VIP-stimulated increases in cAMP levels are obtained in neuron-enriched and in non-neuronal cell-enriched dissociated cultures.