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70962-66-2

中文名稱(chēng) Sparfosic acid trisodium
英文名稱(chēng) Sparfosic acid trisodium
CAS 70962-66-2
分子式 C6H11NNaO8P
分子量 279.12
MOL 文件 70962-66-2.mol
70962-66-2 結(jié)構(gòu)式 70962-66-2 結(jié)構(gòu)式

基本信息

中文別名
N-(膦?;阴;?-L-天門(mén)冬氨酸三鈉鹽
英文別名
Sparfosic acid trisodium

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
形態(tài)Solid-Liquid Mixture
顏色Colorless to off-white
水溶解性Water: 250 mg/mL (778.67 mM)
Sparfosic acid trisodium價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2025/12/22HY-112732BSparfosic acid trisodium70962-66-21 mg1280元
2025/12/22HY-112732BSparfosic acid trisodium
Sparfosic acid trisodium
70962-66-25mg3200元
2025/12/22HY-112732BSparfosic acid trisodium
Sparfosic acid trisodium
70962-66-210mM * 1mLin DMSO3520元

常見(jiàn)問(wèn)題列表

生物活性
Sparfosic acid trisodium 是天門(mén)冬氨酸氨甲酰轉(zhuǎn)移酶 (aspartate transcarbamoyl transferase) 的有效抑制劑,具有抗腫瘤和抗代謝物活性。天冬氨酸氨甲酰轉(zhuǎn)移酶催化第二步 de novo 嘧啶生物合成。
體外研究

Sparfosic acid (PALA) treatment causes apoptosis in the resistant Br1 cells.
Sparfosic acid (PALA, 300 μM) shows progressive accumulation of cells in S phase and activation of an apoptotic pathway leading to cell death.

Cell Cycle Analysis

Cell Line: Br-l and L-2 cell lines established from metastasis in nude mouse injected with the human tumor cell line MDA-MB-435.
Concentration: 300 μM.
Incubation Time: 12, 24 and 48 h.
Result: Cells were predominantly in S phase in both the cell lines, although slightly higher proportion of cells in S phase were noted in L-2 than Brl-3prl cells.

Western Blot Analysis

Cell Line: Br-l and L-2 cell lines.
Concentration: 300 μM.
Incubation Time: 4, 10 and 24 h.
Result: There was moderate difference in the level of phosphorylated Rb proteins seen in the two cell types.
Marked increase in the amount of cyclin A protein was detected in the L-2 cells undergoing apoptosis with the highest level detected at 10 h post-drug treatment.
In contrast, there was no increase in the level of cyclin A seen in the Brl-3prl cells.
Cyclin E protein was found elevated in the L-2 cells and Brl-3prl cells compared to their respective controls.
"70962-66-2" 相關(guān)產(chǎn)品信息
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