71774-13-5
中文名稱
化合物 T28615
英文名稱
ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE
CAS
71774-13-5
分子式
C10H12N5O5PS
分子量
345.27
MOL 文件
71774-13-5.mol
71774-13-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 T28615 英文別名
cAMPS-Sp(S)-Adenosine
Sp cAMPS,SpcAMPS
Rp cAMPS TEA salt
Rp-cAMPS TEA salt
Triethylammoniumsalt
camps,sp-isomer,teasalt
ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE
Adenosine, cyclic 3',5'-[hydrogen (S)-phosphorothioate]
Adenosine-3'',5''-cyclic monophosphothioate sodium salt Sp isomer
物理化學(xué)性質(zhì)
沸點(diǎn)648.0±65.0 °C(predicted)
密度2.38±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
儲(chǔ)存條件Desiccate at -20°C
溶解度water: 20 mg/mL
酸度系數(shù)(pKa)-0.55±0.60(predicted)
形態(tài)crystalline solid
水溶解性water: 20mg/mL
常見問題列表
生物活性
Sp-cAMPS，一種 cAMP 類似物，是一種依賴 cAMP 的 PKA I 和 PKA II 的有效激活劑。Sp-cAMPS 還是一種有效的競爭性磷酸二酯酶 (PDE3A) 抑制劑，Ki 為 47.6 μM。Sp-cAMPS 以 EC50 為 40 μM 來結(jié)合 PDE10 GAF 域。靶點(diǎn)
|
PKA I
|
PKA II
|
PDE3A 47.6 μM (Ki) |
PDE10 GAF domain 50 μM (EC 50 ) |
體外研究
Treatment of hepatocytes with Sp-cAMPS, the stimulatory diastereomer of adenosine cyclic 3',5'-phosphorothioate, mimics the response seen with glucagon. The glucagon-stimulated increases in the level of Ca 2+ can be mimicked by Sp-cAMPS.
體內(nèi)研究
In chronic alcohol consumption (CAC) mice, direct infusion of the Sp-cAMPS (1 μg/μL) into the prefrontal cortex significantly improves or impairs, respectively, working memory performance in withdrawn and water animals.