73326-98-4
中文名稱
5氫-吡啶并[4,3-B]咔唑-5,11(6氫)-二酮
英文名稱
5H-Pyrido[4,3-b]carbazole-5,11(6H)-dione
CAS
73326-98-4
分子式
C15H8N2O2
分子量
248.24
MOL 文件
73326-98-4.mol
73326-98-4 結(jié)構(gòu)式
基本信息
中文別名
5氫-吡啶并[4,3-B]咔唑-5,11(6氫)-二酮 英文別名
5H-Pyrido[4,3-b]carbazole-5,11(6H)-dione 所屬類別
醫(yī)藥中間體：原料藥中間體物理化學(xué)性質(zhì)
熔點>300 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3))
沸點543.0±40.0 °C(Predicted)
密度1.506±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)11.81±0.20(Predicted)
形態(tài)Solid
顏色Light brown to brown
應(yīng)用領(lǐng)域
用途一
Ellipticine quinone, also known as NSC-383230, is a Drp1 inhibitor. rpitor1 and Drpitor1a inhibited the GTPase activity of Drp1 without inhibiting the GTPase of dynamin 1. Ellipticine quinone showed greater potency than the current std. Drp1 GTPase inhibitor, mdivi-?1, (IC50 for mitochondrial fragmentation are (0.06, and 10 μM, resp.)?. Ellipticine quinone suppressed lung cancer tumor growth in a mouse xenograft model. Ellipticine quinone also inhibited mitochondrial ROS prodn., prevented mitochondrial fission, and improved right ventricular diastolic dysfunction during IR injury.